Cdc6 Antibody (180.2): sc-9964

Cdc6 Antibody (180.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cdc6 of mouse, rat, and human origin through western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Cdc6 (180.2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Cdc6 plays a crucial role in the initiation of DNA replication, which is essential for cell division and proper progression of the cell cycle. By ensuring DNA replication occurs at the right time, Cdc6 helps maintain genomic stability and prevents errors that could lead to cell malfunction or disease. Cdc6 is particularly important in cancer research, as dysregulation of Cdc6 can contribute to uncontrolled cell proliferation. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, and interaction with various proteins, such as Cdc37, aids in the formation of the cyclin D1/Cdk4 complex, highlighting an integral role in cell cycle regulation. Additionally, Cdc6 interacts with ubiquitin-conjugating enzymes like Cdc34, Cdc27, and Cdc16, which are involved in the degradation of cyclins, further emphasizing importance in the orchestration of cell cycle events.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Cdc6 Antibody (180.2) References:

1. Stimulation of MCM helicase activity by a Cdc6 protein in the archaeon Thermoplasma acidophilum.  |  Haugland, GT., et al. 2006. Nucleic Acids Res. 34: 6337-44. PMID: 17108356
2. Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55.  |  Boronat, S. and Campbell, JL. 2007. Mol Cell Biol. 27: 1158-71. PMID: 17130241
3. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.  |  Gautier, J., et al. 1991. Cell. 67: 197-211. PMID: 1913817
4. Mitotic transmission of artificial chromosomes in cdc mutants of the yeast, Saccharomyces cerevisiae.  |  Palmer, RE., et al. 1990. Genetics. 125: 763-74. PMID: 2204582
5. CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.  |  Wang, F., et al. 2022. Mol Cancer. 21: 153. PMID: 35879762
6. A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.  |  Mourkioti, I., et al. 2023. J Exp Clin Cancer Res. 42: 187. PMID: 37507762
7. Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance.  |  Cui, J., et al. 2024. Mol Cancer. 23: 86. PMID: 38685067
8. A new twist to the cell cycle.  |  Barinaga, M. 1995. Science. 269: 631-2. PMID: 7624789
9. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.  |  King, RW., et al. 1995. Cell. 81: 279-88. PMID: 7736580
10. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.  |  Plon, SE., et al. 1993. Proc Natl Acad Sci U S A. 90: 10484-8. PMID: 8248134
11. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.  |  Stepanova, L., et al. 1996. Genes Dev. 10: 1491-502. PMID: 8666233
12. A human protein related to yeast Cdc6p.  |  Williams, RS., et al. 1997. Proc Natl Acad Sci U S A. 94: 142-7. PMID: 8990175

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cdc6 Antibody (180.2) has 139 citations in a variety of scientific publications.

Primary antibodies like Anti-Cdc6 Antibody (180.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cdc6 Antibody (180.2) Specifications

Alternate Product Name: Cdc6

Product Clone Name: 180.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cdc6

Epitope Species: human

Product Reactivity/Detection: Cdc6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 139 citations in various scientific publications

Available Conjugates/Forms for Cdc6 Antibody (180.2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, TRITC: Rhodamine