Cdc6 Activators
Common Cdc6 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Forskolin CAS 66575-29-9, Hydroxyurea CAS 127-07-1, Roscovitine CAS 186692-46-6 and MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6.
Cdc6, or Cell Division Cycle 6, is a key regulatory protein that plays an essential role in the initiation of DNA replication in eukaryotic cells. Located in the nucleus, Cdc6 functions as a licensing factor, ensuring that DNA replication occurs only once during each cell cycle. It accomplishes this by assisting in the loading of the MCM (minichromosome maintenance) complex onto the origin of replication, a step that is critical for the formation of the pre-replicative complex (pre-RC). Once this complex is established, it sets the stage for DNA unwinding and the subsequent initiation of replication. Given its central role in ensuring the fidelity of DNA replication, Cdc6 is tightly regulated at both the transcriptional and post-translational levels, ensuring that DNA replication is both accurate and timely.
Activators of Cdc6 are molecules or compounds that promote the expression, stability, or activity of the Cdc6 protein. These activators may function by boosting the transcription of the Cdc6 gene, enhancing the stability of the Cdc6 protein, or promoting its interactions with other components of the pre-RC. The presence of Cdc6 activators can lead to an amplification of the DNA replication initiation process, influencing the cell's progression through the cell cycle. Delving into the world of Cdc6 activators provides insights into the precise molecular choreography that underpins DNA replication initiation. As research continues to elucidate the complex mechanisms that govern cell division and DNA replication, the role of Cdc6 and its activators stands out, highlighting the importance of precise regulatory systems in maintaining genomic integrity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is known to affect cell cycle progression and differentiation. It might influence Cdc6 expression as part of its role in cell cycle regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels and activating PKA, forskolin might influence various cell cycle regulators, potentially including Cdc6. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea stalls replication forks and activates the DNA damage checkpoint. This might influence Cdc6 expression as part of the cellular response to stalled replication. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine inhibits cyclin-dependent kinases and affects cell cycle progression. Its effects on Cdc6 expression would be indirect, stemming from its broader impacts on the cell cycle. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
As a proteasome inhibitor, MG132 affects protein degradation, potentially stabilizing Cdc6 or influencing its expression indirectly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules and activates the spindle assembly checkpoint, potentially affecting Cdc6 expression as part of the checkpoint response. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
This MEK inhibitor might influence Cdc6 expression indirectly through its effects on the ERK/MAPK pathway and cell cycle regulation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
By inhibiting the MDM2-p53 interaction, Nutlin-3 stabilizes p53, which might indirectly influence Cdc6 expression as part of the p53-mediated cell cycle arrest. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
Mimosine induces a G1 cell cycle arrest, potentially influencing the expression of G1/S transition regulators, including Cdc6. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
As a statin, lovastatin can induce cell cycle arrest, potentially influencing Cdc6 expression in the process. | ||||||