CD88 Antibody (3H1740): sc-70813
- CD88 Antibody (3H1740) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a synthetic peptide corresponding to N-terminal amino acids 1-31 of CD88 of human origin
- recommended for detection of CD88 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM; also reactive with additional species, including and bovine and rabbit
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD88 Antibody (3H1740) for WB and IHC(P) applications. These reagents are now offered in bundles with CD88 Antibody (3H1740) (see ordering information below).
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CD88 Antibody (3H1740) is a mouse monoclonal IgG1 antibody that detects CD88 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD88, also known as the C5a receptor (C5aR), is a G protein-coupled integral membrane protein that plays a crucial role in the immune response by serving as a receptor for the inflammatory peptide C5a. The interaction between C5a and CD88 triggers a cascade of inflammatory responses, including increased production of acute phase proteins in the liver, which are vital for the body′s defense mechanisms during inflammation. CD88 is expressed on various immune cells such as neutrophils, monocytes, and macrophages, as well as on hepatocytes and certain epithelial and endothelial cells, highlighting CD88′s importance in mediating inflammation across different tissues. Elevated levels of CD88 have been associated with inflammatory conditions in the brain, and research suggests CD88′s involvement in the pathogenesis of diseases such as rheumatoid arthritis. Human bronchial epithelial cells exhibit heightened responsiveness to C5a when exposed to environmental irritants like cigarette smoke, underscoring CD88′s relevance in respiratory inflammation.
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CD88 Antibody (3H1740) References:
- The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury. | Brennan, FH., et al. 2015. J Neurosci. 35: 6517-31. PMID: 25904802
- C5a receptor enhances hepatocellular carcinoma cell invasiveness via activating ERK1/2-mediated epithelial-mesenchymal transition. | Hu, WH., et al. 2016. Exp Mol Pathol. 100: 101-8. PMID: 26475622
- C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression. | Zhang, K., et al. 2017. Int Immunopharmacol. 53: 17-23. PMID: 29031143
- Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression. | Chen, J., et al. 2018. Cancer Lett. 412: 30-36. PMID: 29031586
- Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD-L1 expression by C5a. | Imamura, R., et al. 2021. Prostate. 81: 147-156. PMID: 33368414
- Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis. | Wang, R., et al. 2021. Aging (Albany NY). 13: 8588-8598. PMID: 33714207
- Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. | Apostolidis, SA., et al. 2022. Front Immunol. 13: 834988. PMID: 35309299
- Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retinal pigment epithelial cells to oxidative stress. | Ishii, M. and Rohrer, B. 2023. Biochim Biophys Acta Gen Subj. 1867: 130374. PMID: 37187450
- Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients. | Liu, X., et al. 2024. Clin Immunol. 259: 109871. PMID: 38101498
- Complement C5a Receptor Signaling in Macrophages Enhances Trained Immunity Through mTOR Pathway Activation. | Shim, EH., et al. 2024. Immune Netw. 24: e24. PMID: 39246622
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD88 Antibody (3H1740) | sc-70813 | 200 µg/ml | $316.00 | |||
CD88 Antibody (3H1740): m-IgG Fc BP-HRP Bundle | sc-537194 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD88 Antibody (3H1740): m-IgGκ BP-HRP Bundle | sc-534398 | 200 µg Ab; 40 µg BP | $354.00 | |||
CD88 Antibody (3H1740) FITC | sc-70813 FITC | 200 µg/ml | $330.00 | |||
CD88 Antibody (3H1740) PE | sc-70813 PE | 200 µg/ml | $343.00 |