CD74 Antibody (PIN.1): sc-47742

CD74 Antibody (PIN.1) is a mouse monoclonal IgG1 antibody that detects CD74 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules. This process is vital for the proper presentation of antigens to T lymphocytes, which is essential for initiating adaptive immune responses. The interaction between CD74 and MHC II occurs during the transport of MHC II to the endosomal compartment, where peptide binding takes place. Notably, CD74 is expressed in a wide range of immune cells, particularly in B lymphocytes, and CD74 expression is critical for the development and function of these cells. Understanding CD74′s role in antigen presentation not only highlights CD74′s importance in immune responses but also underscores CD74′s potential as a therapeutic target in diseases where immune regulation is disrupted. Anti-CD74 antibody (PIN.1) is an invaluable tool for researchers studying immune function and related pathologies.

The preferred CD74 antibody is CD74 Antibody (LN-2): sc-6262.