CD71/TFRC/Transferrin Receptor Antibody (b3/25): sc-65877

CD71 Antibody (b3/25) is a mouse monoclonal IgG1 antibody that detects CD71 in human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that plays a crucial role in iron homeostasis by facilitating cellular uptake of iron through receptor-mediated endocytosis. Anti-CD71 antibody (b3/25) recognizes a disulfide-linked homodimer that binds to two molecules of transferrin, which is essential for transporting iron into cells, particularly in proliferating cells, reticulocytes, and erythroid precursors. CD71 expression is typically high in these cell types, while resting leukocytes do not express CD71; however, CD71 is upregulated upon activation of lymphocytes, monocytes, and macrophages, highlighting CD71′s importance in immune responses and cellular proliferation. CD71 is present on most dividing cells and brain endothelium, indicating CD71′s widespread role in various physiological processes. Understanding CD71 function is vital, as mutations in the TFR gene can lead to hereditary hemochromatosis type III, an iron overload disorder that predominantly affects Caucasians, underscoring CD71′s significance in both health and disease. CD71 (b3/25) monoclonal antibody serves as an invaluable tool for researchers studying iron metabolism and related disorders.

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.