CD69 Antibody (A-5): sc-373798
- CD69 Antibody (A-5) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-199 representing full length CD69 of human origin
- recommended for detection of CD69 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD69 Antibody (A-5) for WB applications. These reagents are now offered in bundles with CD69 Antibody (A-5) (see ordering information below).
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CD69 Antibody (A-5) is a mouse monoclonal IgG2b antibody that detects CD69 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD69 is a crucial activation marker expressed as a disulfide-linked homodimer known as the activation inducer molecule (AIM), which consists of two differentially glycosylated forms of a single protein. CD69 (A-5) antibody plays a significant role in studying immune response, as CD69 is one of the earliest antigens to appear following the activation of T cells, B cells, and natural killer (NK) cells. Notably, CD69 is constitutively expressed on platelets, CD4+ or CD8+ thymocytes, and germinal center T cells, while remaining absent from resting lymphocytes, highlighting CD69′s importance in distinguishing between activated and resting immune cells. CD69 (A-5) monoclonal antibody serves as a critical tool for researchers studying immune responses and related pathways by detecting CD69 expression on activated lymphocytes.
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CD69 Antibody (A-5) References:
- CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production. | Yu, L., et al. 2018. Cell Death Dis. 9: 905. PMID: 30185773
- CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. | Kimura, MY., et al. 2018. Nat Commun. 9: 3749. PMID: 30218105
- CD69+ resident memory T cells are associated with graft-versus-host disease in intestinal transplantation. | Weiner, J., et al. 2021. Am J Transplant. 21: 1878-1892. PMID: 33226726
- CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system. | Nakayama, T., et al. 2021. Int Immunol. 33: 699-704. PMID: 34427648
- CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection. | Jiang, Y., et al. 2021. Clin Transl Med. 11: e563. PMID: 34841721
- Intrahepatic CD69+Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression. | Bruni, E., et al. 2022. J Immunother Cancer. 10: PMID: 35863820
- Tissue-resident CD69+ CXCR6+ Natural Killer cells with exhausted phenotype accumulate in human non-small cell lung cancer. | Chen, X., et al. 2022. Eur J Immunol. 52: 1993-2005. PMID: 36205624
- Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin. | Koizume, S., et al. 2023. Cancer Sci. 114: 2485-2498. PMID: 36854451
- CD69 on Tumor-Infiltrating Cells Correlates With Neuroblastoma Suppression by Simultaneous PD-1 and PD-L1 Blockade. | Inoue, S., et al. 2023. J Surg Res. 289: 190-201. PMID: 37141702
- CD69 marks a subpopulation of acute myeloid leukemia with enhanced colony forming capacity and a unique signaling activation state. | Antony, ML., et al. 2023. Leuk Lymphoma. 64: 1262-1274. PMID: 37161853
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD69 Antibody (A-5) | sc-373798 | 200 µg/ml | $322.00 | |||
CD69 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-535314 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD69 Antibody (A-5): m-IgG2b BP-HRP Bundle | sc-549389 | 200 µg Ab; 10 µg BP | $361.00 |