CD5 Antibody (H-3): sc-393087

CD5 Antibody (H-3) is a mouse monoclonal IgG2b antibody that detects CD5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD5 is a crucial transmembrane glycoprotein predominantly expressed on T lymphocytes, where CD5 plays a significant role in modulating T cell activation and signaling. Located on the surface of these immune cells, CD5 interacts with the T cell receptor (TCR) and the CD3-ζ chain, facilitating a complex signaling cascade that is essential for T cell function. Notably, the activation of T cells through the TCR leads to the tyrosine phosphorylation of CD5, which is vital for maintaining the balance of T cell responses; without CD5, T cells can become hyper-responsive, potentially leading to autoimmune disorders. Additionally, CD5′s interaction with the Src family kinase Lck enhances the kinase′s activity significantly, underscoring CD5′s importance in T cell signaling pathways. CD5′s binding to CD72 is also a subject of ongoing research, as this interaction may influence thymic selection processes, further highlighting CD5′s critical role in immune system regulation. Anti-CD5 antibody (H-3) serves as an invaluable tool for researchers studying T cell biology and the intricate mechanisms of immune responses.

The preferred CD5 antibody is CD5 Antibody (UCH-T2): sc-1180.