CD40 Antibody (BE-1): sc-65263

CD40 Antibody (BE-1) is a mouse monoclonal IgG1 antibody that detects CD40 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD40 is a crucial co-stimulatory receptor found on the surface of B cells, playing a vital role in the activation and proliferation of these immune cells in response to signals from activated T helper cells. The interaction between CD40 and its ligand, CD40L, is essential for initiating a cascade of intracellular signaling that leads to B cell activation, immunoglobulin class switching, and the production of antibodies, including IgE. This process is particularly important for the adaptive immune response, as CD40 enables B cells to produce specific antibodies that target pathogens effectively. Furthermore, CD40 signaling is intricately linked to various post-translational modifications, including ubiquitination, which can influence the stability and activity of CD40, thereby modulating the immune response. Anti-CD40 antibody (BE-1) is an invaluable tool for researchers studying B cell biology and the mechanisms underlying immune responses, providing insights into potential therapeutic targets for immunological disorders.

The preferred CD40 antibody is CD40 Antibody (H-10): sc-13128.