CD38 Antibody (H-11): sc-374650

CD38 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD38 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD38 Antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD38 is a type II integral membrane glycoprotein that plays a crucial role in immune response, being expressed on early B and T cell lineages, activated B and T cells, and other immune cells such as thymocytes and monocytes. CD38 is primarily located on the cell surface, where CD38 functions as a signaling receptor and an enzyme, catalyzing the hydrolysis of NAD+ to produce cyclic adenosine diphosphate ribose (cADPR), a potent calcium-mobilizing second messenger. This function is vital for the activation, proliferation, and differentiation of T and B cells, as well as for mediating apoptosis in myeloid and lymphoid progenitor cells. Furthermore, CD38 is essential for the survival of invariant natural killer T (iNKT) cells, which are important for maintaining immunological tolerance. CD38′s ability to generate cADPR highlights CD38′s significance in calcium signaling pathways, which are critical for various cellular processes, including cell activation and communication within the immune system.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD38 Antibody (H-11) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-CD38 Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD38 Antibody (H-11) Specifications

Alternate Product Name: CD38

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-170

Epitope Target: CD38

Epitope Species: human

Product Reactivity/Detection: CD38

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for CD38 Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CD38 antibody is CD38 Antibody (AT13/5): sc-59028.