CD38 Antibody (AT13/5): sc-59028

CD38 Antibody (AT13/5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD38 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD38 Antibody (AT13/5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD38 is a type II integral membrane glycoprotein predominantly located on early B and T cell lineages, activated B and T cells, and is notably absent from most mature resting peripheral lymphocytes. CD38′s presence on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes, and immunoglobulin-secreting plasma cells highlights CD38′s critical role in immune response. Functionally, CD38 acts as a NAD glycohydrolase, facilitating the activation, proliferation, and differentiation of mature T and B cells while also mediating apoptosis in myeloid and lymphoid progenitor cells. Beyond CD38′s role as a signaling receptor, CD38 is an enzyme that generates several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR), which are essential for various cellular processes. Furthermore, CD38 is vital for the survival of invariant natural killer T (iNKT) cells, which are crucial for maintaining immunological tolerance, thereby underscoring CD38′s importance in both adaptive and innate immunity.

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CD38 Antibody (AT13/5) References:

1. CD38 molecule: structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells.  |  Alessio, M., et al. 1990. J Immunol. 145: 878-84. PMID: 1695648
2. CD38: A Potential Therapeutic Target in Cardiovascular Disease.  |  Zuo, W., et al. 2021. Cardiovasc Drugs Ther. 35: 815-828. PMID: 32472237
3. Targeting CD38 in Neoplasms and Non-Cancer Diseases.  |  Szlasa, W., et al. 2022. Cancers (Basel). 14: PMID: 36077708
4. CD38 expression by plasma cells in extramedullary multiple myeloma.  |  Notarfranchi, L., et al. 2024. Haematologica. 109: 1297-1300. PMID: 37941401
5. Murine CD38: an immunoregulatory ectoenzyme.  |  Lund, F., et al. 1995. Immunol Today. 16: 469-73. PMID: 7576049
6. CD38 expression on mouse T cells: CD38 defines functionally distinct subsets of alpha beta TCR+CD4-CD8- thymocytes.  |  Bean, AG., et al. 1995. Int Immunol. 7: 213-21. PMID: 7734417
7. Ligation of CD38 suppresses human B lymphopoiesis.  |  Kumagai, M., et al. 1995. J Exp Med. 181: 1101-10. PMID: 7869031
8. Murine B-cell activation via CD38 and protein tyrosine phosphorylation.  |  Kirkham, PA., et al. 1994. Immunology. 83: 513-6. PMID: 7875731
9. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.  |  Howard, M., et al. 1993. Science. 262: 1056-9. PMID: 8235624
10. Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38.  |  Harada, N., et al. 1993. J Immunol. 151: 3111-8. PMID: 8376770
11. A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels.  |  Santos-Argumedo, L., et al. 1993. J Immunol. 151: 3119-30. PMID: 8397252
12. Lymphocyte adhesion to endothelium.  |  Dianzani, U. and Malavasi, F. 1995. Crit Rev Immunol. 15: 167-200. PMID: 8573287

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD38 Antibody (AT13/5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CD38 Antibody (AT13/5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD38 Antibody (AT13/5) Specifications

Alternate Product Name: CD38

Product Clone Name: AT13/5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD38

Epitope Species: human

Product Reactivity/Detection: CD38

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CD38 Antibody (AT13/5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin