CD37 Antibody (HH1): sc-18881
- CD37 Antibody (HH1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against lymphoma cells from a patient with follicular lymphoma
- CD37 Antibody (HH1) is recommended for detection of CD37 of human origin by FCM
- Anti-CD37 Antibody (HH1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD37 Antibody (HH1). These reagents are now offered in bundles with CD37 Antibody (HH1) (see ordering information below).
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CD37 Antibody (HH1) is a mouse monoclonal IgG1 kappa light chain antibody that detects human CD37 by flow cytometry (FCM). Anti-CD37 antibody (HH1) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD37 is a member of the tetra-span transmembrane family (TSTF), which includes other cell-surface proteins such as CD9, CD53, CD63, CD81, and CD82, all characterized by their four hydrophobic, membrane-spanning domains. These proteins are crucial for mediating signal transduction events that influence cell development, adhesion, activation, growth, and motility. The human CD37 gene is located on chromosome 19p13-q13.4 and encodes a 281 amino acid glycoprotein that plays a significant role in T-cell and B-cell interactions by forming complexes with integrins and other TSTF proteins. CD37 is predominantly expressed on normal and neoplastic mature sIg+ B cells, while showing lower expression on resting and activated T cells, neutrophils, granulocytes, and monocytes. Studies using transgenic mouse models lacking CD37 have shown no significant changes in the development and cellular composition of lymphoid organs, underscoring CD37′s importance in immune system regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD37 Antibody (HH1) References:
- Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. | Knobeloch, KP., et al. 2000. Mol Cell Biol. 20: 5363-9. PMID: 10891477
- Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production. | Meyer-Wentrup, F., et al. 2007. J Immunol. 178: 154-62. PMID: 17182550
- Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. | Zhao, X., et al. 2007. Blood. 110: 2569-77. PMID: 17440052
- A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. | Gartlan, KH., et al. 2010. J Immunol. 185: 3158-66. PMID: 20709950
- The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. | Classon, BJ., et al. 1989. J Exp Med. 169: 1497-502. PMID: 2466944
- The tetraspanin superfamily: molecular facilitators. | Maecker, HT., et al. 1997. FASEB J. 11: 428-42. PMID: 9194523
- Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with alpha 3 beta 1 integrin. | Okochi, H., et al. 1997. Br J Dermatol. 137: 856-63. PMID: 9470900
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD37 Antibody (HH1) | sc-18881 | 200 µg/ml | $322.00 | |||
CD37 Antibody (HH1): m-IgG Fc BP-HRP Bundle | sc-528338 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD37 Antibody (HH1): m-IgGκ BP-HRP Bundle | sc-520690 | 200 µg Ab, 40 µg BP | $361.00 | |||
CD37 Antibody (HH1): m-IgG1 BP-HRP Bundle | sc-542876 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD37 Antibody (HH1) AC | sc-18881 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD37 Antibody (HH1) HRP | sc-18881 HRP | 200 µg/ml | $322.00 | |||
CD37 Antibody (HH1) FITC | sc-18881 FITC | 200 µg/ml | $336.00 | |||
CD37 Antibody (HH1) PE | sc-18881 PE | 200 µg/ml | $349.00 | |||
CD37 Antibody (HH1) Alexa Fluor® 488 | sc-18881 AF488 | 200 µg/ml | $364.00 | |||
CD37 Antibody (HH1) Alexa Fluor® 546 | sc-18881 AF546 | 200 µg/ml | $364.00 | |||
CD37 Antibody (HH1) Alexa Fluor® 594 | sc-18881 AF594 | 200 µg/ml | $364.00 | |||
CD37 Antibody (HH1) Alexa Fluor® 647 | sc-18881 AF647 | 200 µg/ml | $364.00 | |||
CD37 Antibody (HH1) Alexa Fluor® 680 | sc-18881 AF680 | 200 µg/ml | $364.00 | |||
CD37 Antibody (HH1) Alexa Fluor® 790 | sc-18881 AF790 | 200 µg/ml | $364.00 |