CD35 Antibody (Ber-MAC-DRC): sc-19662

CD35 Antibody (Ber-MAC-DRC) is a mouse monoclonal IgG1 antibody that detects CD35 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD35, also known as complement receptor 1 (CR1), plays a crucial role in the immune response by serving as a receptor for complement components C3b and C4b, facilitating the phagocytosis of opsonized particles by neutrophils and monocytes. This function is vital for the clearance of pathogens and immune complexes, thereby maintaining homeostasis and preventing excessive inflammation. CD35 is predominantly expressed on granulocytes, monocytes, B cells, some natural killer cells, and erythrocytes, highlighting its importance in various immune processes. Notably, alterations in CD35 expression and function have been implicated in systemic lupus erythematosus (SLE), a chronic autoimmune disease characterized by the production of a wide array of autoantibodies and immune complex accumulation. In SLE patients, there is an observed increase in the proteolytic cleavage of leukocyte surface CD35, which may contribute to the dysregulation of immune responses. Sequence analysis indicates that Crry may serve as the mouse genetic homolog of the human CD35 antigen encoded by the CR1 gene, further underscoring the relevance of this protein in both human and murine models of immune function. CD35 (Ber-MAC-DRC) antibody is an essential tool for researchers investigating the complexities of immune regulation and the pathogenesis of autoimmune diseases.

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CD35 Antibody (Ber-MAC-DRC) References:

1. Role of complement receptors CD21/CD35 in B lymphocyte activation and survival.  |  Carroll, M. 1999. Curr Top Microbiol Immunol. 246: 63-8; discussion 69. PMID: 10396040
2. The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35).  |  Liu, D. and Niu, ZX. 2009. Immunopharmacol Immunotoxicol. 31: 524-35. PMID: 19874218
3. Complement receptor type 1 (C3b/C4b receptor; CD35) and complement receptor type 2 (C3d/Epstein-Barr virus receptor; CD21).  |  Fearon, DT. and Ahearn, JM. 1990. Curr Top Microbiol Immunol. 153: 83-98. PMID: 2153507
4. Deficiencies of human C3 complement receptors type 1 (CR1, CD35) and type 2 (CR2, CD21).  |  Kazatchkine, MD. and Fearon, DT. 1990. Immunodefic Rev. 2: 17-41. PMID: 2164822
5. Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis.  |  Piccoli, AK., et al. 2011. Rev Bras Reumatol. 51: 503-10. PMID: 21953001
6. CD35 and CD64 of Neutrophils Can Differentiate Between Bacterial and Viral Infections in Children by Simultaneous Quantitative Analysis.  |  Lu, L., et al. 2019. Med Sci Monit. 25: 7728-7734. PMID: 31612870
7. Modulation in the expression of type 1 (CR1/CD35) and type 3 (CR3/CD11b) complement receptors on leukocytes from patients with Visceral leishmaniasis.  |  Campelo, CM., et al. 2020. Exp Parasitol. 218: 107970. PMID: 32828829
8. Genetic Polymorphisms in CD35 Gene Contribute to the Susceptibility and Prognosis of Hepatocellular Carcinoma.  |  Luo, L., et al. 2021. Front Oncol. 11: 700711. PMID: 34422654
9. Isolation of CD35+ follicular dendritic cells and its role in the differentiation from B cells to IgA+GL7+ cells.  |  Hikosaka-Kuniishi, M., et al. 2022. Immunol Lett. 243: 53-60. PMID: 35167919
10. Distribution of C3-step regulatory proteins of the complement system, CD35 (CR1), CD46 (MCP), and CD55 (DAF), in hematological malignancies.  |  Seya, T., et al. 1994. Leuk Lymphoma. 12: 395-400. PMID: 7514063

The preferred CD35 antibody is CD35 Antibody (To5): sc-20055.