CD206/Mannose Receptor/MMR Antibody (D-1): sc-376108

CD206 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody raised against amino acids 1090-1389 within the extracellular domain of human CD206, detecting CD206 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD206, also known as the Mannose Receptor (MR), Macrophage Mannose Receptor (MMR), or Mannose Receptor C Type 1 (MRC1), is a type I membrane receptor protein predominantly expressed on macrophages, immature dendritic cells, hepatic and lymphatic endothelial cells, retinal pigment epithelium (RPE), and mesangial cells. CD206 undergoes significant post-translational modifications, particularly N-linked glycosylation, which is crucial for proper folding, stability, and ligand-binding activity. N-linked glycosylation of CD206 enhances recognition and binding of carbohydrate ligands on pathogen surfaces, facilitating endocytosis and neutralization by phagocytic cells. The extracellular portion of CD206 includes eight C-type lectin-like carbohydrate recognition domains (CRDs) clustered together to provide high-affinity binding to saccharides, and multiple CRDs distinguish CD206 from other C-type lectins. Through mediation of glycoprotein endocytosis and phagocytic engulfment of pathogens, CD206 plays a critical role in innate immunity and rapid clearance of mannose-bearing serum glycoproteins during inflammation. anti-CD206 antibody (D-1) serves as a valuable tool for researchers studying expression, post-translational modifications, and function of CD206, contributing to advancements in immunological research and potential therapeutic developments.

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CD206/Mannose Receptor/MMR Antibody (D-1) References:

1. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor.  |  Feinberg, H., et al. 2000. J Biol Chem. 275: 21539-48. PMID: 10779515
2. Mannose receptor-mediated regulation of serum glycoprotein homeostasis.  |  Lee, SJ., et al. 2002. Science. 295: 1898-901. PMID: 11884756
3. Organization of the gene encoding the human macrophage mannose receptor (MRC1).  |  Kim, SJ., et al. 1992. Genomics. 14: 721-7. PMID: 1294118
4. Characterization of the murine macrophage mannose receptor: demonstration that the downregulation of receptor expression mediated by interferon-gamma occurs at the level of transcription.  |  Harris, N., et al. 1992. Blood. 80: 2363-73. PMID: 1421407
5. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor.  |  Taylor, ME., et al. 1992. J Biol Chem. 267: 1719-26. PMID: 1730714
6. Association of CD206 Protein Expression with Immune Infiltration and Prognosis in Patients with Triple-Negative Breast Cancer.  |  Bobrie, A., et al. 2022. Cancers (Basel). 14: PMID: 36230752
7. CD206+/MHCII- macrophage accumulation at nerve injury site correlates with attenuation of allodynia in TASTPM mouse model of Alzheimer's disease.  |  Silva, R., et al. 2022. Brain Behav Immun Health. 26: 100548. PMID: 36388139
8. Relevance of TMPRSS2, CD163/CD206, and CD33 in clinical severity stratification of COVID-19.  |  Martínez-Diz, S., et al. 2022. Front Immunol. 13: 1094644. PMID: 36969980
9. Evaluation of a CD206-Targeted Peptide for PET Imaging of Macrophages in Syngeneic Mouse Models of Cancer.  |  Parker, CC., et al. 2023. Mol Pharm. 20: 2415-2425. PMID: 37014648
10. Assignment of the human macrophage mannose receptor gene (MRC1) to 10p13 by in situ hybridization and PCR-based somatic cell hybrid mapping.  |  Eichbaum, Q., et al. 1994. Genomics. 22: 656-8. PMID: 8001982
11. The exon-intron structure and chromosomal localization of the mouse macrophage mannose receptor gene Mrc1: identification of a Ricin-like domain at the N-terminus of the receptor.  |  Harris, N., et al. 1994. Biochem Biophys Res Commun. 198: 682-92. PMID: 8297379
12. The mannose receptor is a pattern recognition receptor involved in host defense.  |  Stahl, PD. and Ezekowitz, RA. 1998. Curr Opin Immunol. 10: 50-5. PMID: 9523111

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD206/Mannose Receptor/MMR Antibody (D-1) has 36 citations in a variety of scientific publications.

Primary antibodies like Anti-CD206/Mannose Receptor/MMR Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD206/Mannose Receptor/MMR Antibody (D-1) Specifications

Alternate Product Name: MRC1

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1090-1389

Epitope Target: CD206

Epitope Species: human

Product Reactivity/Detection: CD206

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 36 citations in various scientific publications

Available Conjugates/Forms for CD206/Mannose Receptor/MMR Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin