CD2 Antibody (Huly-m1): sc-7318
- CD2 Antibody (Huly-m1) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against pooled donor human thymocytes
- recommended for detection of CD2 of human origin by WB, IP and FCM
- available conjugated to agarose for IP; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (Huly-m1) for WB applications. These reagents are now offered in bundles with CD2 Antibody (Huly-m1) (see ordering information below).
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CD2 Antibody (Huly-m1) is a mouse monoclonal IgG2b antibody that detects CD2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. Its primary function is to mediate cell adhesion by interacting with CD58, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, as it facilitates communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (Huly-m1) provides a reliable tool for researchers studying T cell activation and immune interactions, contributing to a deeper understanding of immune system dynamics.
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CD2 Antibody (Huly-m1) References:
- CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization. | Sasada, T., et al. 2002. J Immunol. 168: 1113-22. PMID: 11801645
- Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. | Freund, C., et al. 2002. EMBO J. 21: 5985-95. PMID: 12426371
- CD2+ acute promyelocytic leukemia is associated with leukocytosis, variant morphology and poorer prognosis. | Kaito, K., et al. 2005. Clin Lab Haematol. 27: 307-11. PMID: 16178910
- CD2 activation of human lamina propria lymphocytes reduces CD3 responsiveness. | Ebert, EC. 2006. Immunology. 117: 71-7. PMID: 16423042
- CD2 can mediate TCR/CD3-independent T cell activation. | Ohno, H., et al. 1991. J Immunol. 146: 3742-6. PMID: 1674520
- Stimulation of CD2-negative T cells by staphylococcal enterotoxin superantigens. | Duan, XC. and Kabelitz, D. 1991. Immunol Lett. 29: 219-22. PMID: 1685147
- CD2 promotes human natural killer cell membrane nanotube formation. | Comerci, CJ., et al. 2012. PLoS One. 7: e47664. PMID: 23112830
- CD2-positive follicular lymphoma complicated by venous thrombus of surface vein. | Tabata, R., et al. 2014. Ann Hematol. 93: 517-9. PMID: 23783423
- A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice. | Arulanandam, AR., et al. 1993. J Exp Med. 177: 1439-50. PMID: 7683037
- CD2 signalling induces phosphorylation of CREB in primary lymphocytes. | Guyot, DJ., et al. 1998. Immunology. 95: 544-52. PMID: 9893043
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (Huly-m1) | sc-7318 | 200 µg/ml | $322.00 | |||
CD2 Antibody (Huly-m1): m-IgG Fc BP-HRP Bundle | sc-536556 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (Huly-m1): m-IgGκ BP-HRP Bundle | sc-533707 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD2 Antibody (Huly-m1): m-IgG2b BP-HRP Bundle | sc-549810 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (Huly-m1) AC | sc-7318 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD2 Antibody (Huly-m1)=FITC) FITC | sc-7318 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (Huly-m1) PE | sc-7318 PE | 200 µg/ml | $349.00 |