CD1A Antibody (HI149): sc-19636
- CD1A Antibody (HI149) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against human thymocytes
- recommended for detection of CD1A of human origin by IF and FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- See CD1A (O10): sc-18885 for CD1A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD1A Antibody (HI149). These reagents are now offered in bundles with CD1A Antibody (HI149) (see ordering information below).
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CD1A Antibody (HI149) is a mouse monoclonal IgG1 antibody that detects CD1A in human samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). CD1A plays a crucial role in the immune system by presenting lipid antigens to T lymphocytes, which is essential for the recognition of non-peptide antigens and the activation of specific immune responses. CD1A is primarily located on the surface of Langerhans cells, a specialized type of dendritic cell found in the skin, where CD1A contributes to the initiation of immune responses against pathogens. CD1A expression on these cells is particularly important for the diagnosis of Langerhans cell histiocytosis (LCH), a rare disorder characterized by the proliferation of Langerhans cells. CD1A is also involved in the trafficking and activation of CD1-restricted T cells, with CD1A expression regulated by adaptor-protein complexes and chaperones that ensure proper localization and function. Anti-CD1A antibody (HI149) enables researchers to gain valuable insights into the mechanisms of lipid antigen presentation and the role of Langerhans cells in immune responses, making CD1A (HI149) monoclonal antibody a vital tool for studies in immunology and related fields.
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CD1A Antibody (HI149) References:
- Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia. | Sánchez-Martínez, D., et al. 2019. Blood. 133: 2291-2304. PMID: 30796021
- CD1a selectively captures endogenous cellular lipids that broadly block T cell response. | Cotton, RN., et al. 2021. J Exp Med. 218: PMID: 33961028
- Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System. | Yoo, HJ., et al. 2021. Mol Cells. 44: 310-317. PMID: 33980746
- Immunolocalization of CD1a expressing dendritic cells in sinonasal polyposis. | Jayasekhar, R., et al. 2022. J Immunoassay Immunochem. 43: 403-419. PMID: 35147059
- Monitoring Circulating CD207+CD1a+ Cells in Langerhans Cell Histiocytosis and Clinical Implications. | Olexen, CM., et al. 2022. J Immunol. 209: 270-279. PMID: 35768149
- Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors. | Wegrecki, M., et al. 2022. Nat Commun. 13: 3872. PMID: 35790773
- Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a. | Monnot, GC., et al. 2023. Nat Immunol. 24: 110-122. PMID: 36550321
- Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation. | Chen, YL., et al. 2023. Sci Immunol. 8: eadd9232. PMID: 37267382
- CD1a and bound lipids drive T-cell responses in human skin disease. | Ogg, GS., et al. 2023. Eur J Immunol. 53: e2250333. PMID: 37539748
- Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency. | Kobiela, A., et al. 2024. Front Immunol. 15: 1369238. PMID: 38585273
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD1A Antibody (HI149) | sc-19636 | 200 µg/ml | $322.00 | |||
CD1A Antibody (HI149): m-IgG Fc BP-HRP Bundle | sc-536625 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD1A Antibody (HI149): m-IgGκ BP-HRP Bundle | sc-533782 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD1A Antibody (HI149): m-IgG1 BP-HRP Bundle | sc-544714 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD1A Antibody (HI149) Alexa Fluor® 488 | sc-19636 AF488 | 200 µg/ml | $364.00 | |||
CD1A Antibody (HI149) Alexa Fluor® 647 | sc-19636 AF647 | 200 µg/ml | $364.00 | |||
CD1A Antibody (HI149) FITC | sc-19636 FITC | 200 µg/ml | $336.00 | |||
CD1A Antibody (HI149) PE | sc-19636 PE | 200 µg/ml | $349.00 |