CCK-4 Antibody (WW02): sc-100304

CCK-4 Antibody (WW02) is a mouse monoclonal IgG2b kappa light chain antibody that detects CCK-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CCK-4 antibody (WW02) is available as the non-conjugated format. Cholecystokinin (CCK) plays a crucial role as a brain/gut peptide, primarily involved in stimulating the release of pancreatic enzymes and promoting gallbladder contraction, which is essential for digestion and nutrient absorption. The CCK precursor undergoes cleavage to yield active peptides, including CCK58, which further underscores CCK′s importance in digestive processes. CCK-4, a Type I membrane protein belonging to the Tyr family of protein kinases and the insulin receptor subfamily, is notable for lacking the typical tyrosine kinase catalytic activity, suggesting a potential role in cell adhesion rather than in signaling pathways. CCK-4 is considered a potential tumor progression marker and may be implicated in the pathophysiology of colon carcinoma. CCK-4 is predominantly expressed in the pancreas, liver, lung, placenta, kidney, and melanocytes, while absent in the colon but can be detected in erythroleukemia cells, highlighting CCK-4′s diverse expression profile and potential relevance in various biological contexts.

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CCK-4 Antibody (WW02) References:

1. Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA.  |  Jung, JW., et al. 2002. Biochim Biophys Acta. 1579: 153-63. PMID: 12427550
2. Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus.  |  Daigo, Y., et al. 2004. J Gastroenterol. 39: 238-41. PMID: 15065000
3. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.  |  Lu, X., et al. 2004. Nature. 430: 93-8. PMID: 15229603
4. The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions.  |  Kobus, FJ. and Fleming, KG. 2005. Biochemistry. 44: 1464-70. PMID: 15683231
5. CCK-4: Psychophysiological conditioning elicits features of spontaneous panic attacks.  |  Hinkelmann, K., et al. 2010. J Psychiatr Res. 44: 1148-53. PMID: 20451215
6. Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males.  |  Goettel, M., et al. 2023. CNS Drugs. 37: 1099-1109. PMID: 38019356
7. Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.  |  Mossie, K., et al. 1995. Oncogene. 11: 2179-84. PMID: 7478540
8. A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.  |  Lee, ST., et al. 1993. Oncogene. 8: 3403-10. PMID: 8247543
9. CCK-4-induced calcium mobilization in T cells is enhanced in panic disorder.  |  Akiyoshi, J., et al. 1996. J Neurochem. 66: 1610-6. PMID: 8627317
10. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.  |  Park, SK., et al. 1996. J Biochem. 119: 235-9. PMID: 8882711
11. Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1-->p12.2 by fluorescence in situ hybridization.  |  Banga, SS., et al. 1997. Cytogenet Cell Genet. 76: 43-4. PMID: 9154124
12. Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma.  |  Easty, DJ., et al. 1997. Int J Cancer. 71: 1061-5. PMID: 9185712

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CCK-4 Antibody (WW02) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CCK-4 Antibody (WW02) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CCK-4 Antibody (WW02) Specifications

Alternate Product Name: CCK-4

Product Clone Name: WW02

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 36-146

Epitope Target: CCK-4

Epitope Species: human

Product Reactivity/Detection: mature CCK-4 and CCK-4 precursor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CCK-4 Antibody (WW02): N/A