CCDC18 Antibody (G-5): sc-515316
- CCDC18 Antibody (G-5) is a mouse monoclonal IgG2b κ CCDC18 antibody provided at 200 µg/ml
- raised against amino acids 801-933 mapping within an internal region of CCDC18 of human origin
- CCDC18 Antibody (G-5) is recommended for detection of CCDC18 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CCDC18 Antibody (G-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCDC18 Antibody (G-5) for WB applications. These reagents are now offered in bundles with CCDC18 Antibody (G-5) (see ordering information below).
CCDC18 Antibody (G-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects CCDC18 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CCDC18 antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCDC18, also known as NY-SAR-41 or dJ717I23.1, is a 1,454 amino acid protein that plays a crucial role in cellular processes, particularly in forming coiled-coil structures essential for protein-protein interactions. These interactions are vital for various cellular functions, including signal transduction and structural integrity of the cytoskeleton. CCDC18′s ability to form these structures underscores its importance in maintaining cellular architecture and facilitating communication between proteins, which can have significant implications in understanding diseases where these processes are disrupted. Encoded by a gene located on human chromosome 1, CCDC18 is expressed as two isoforms and is associated with a range of genetic disorders linked to chromosomal abnormalities. Chromosome 1 is the largest human chromosome and is implicated in various diseases, including certain cancers and genetic syndromes, making CCDC18 study particularly relevant in molecular biology and disease research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCDC18 Antibody (G-5) References:
- Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. | Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
- New insights into the evolution of chromosome 1. | Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
- Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. | McClintock, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 2154-9. PMID: 16461887
- Cell biology: ageing nucleus gets out of shape. | Lans, H. and Hoeijmakers, JH. 2006. Nature. 440: 32-4. PMID: 16511477
- Chromosome 1 abnormalities in multiple myeloma. | Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
- Lamin A-dependent nuclear defects in human aging. | Scaffidi, P. and Misteli, T. 2006. Science. 312: 1059-63. PMID: 16645051
- Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. | Hennah, W., et al. 2006. Schizophr Bull. 32: 409-16. PMID: 16699061
- The DNA sequence and biological annotation of human chromosome 1. | Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
- Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. | Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCDC18 Antibody (G-5) | sc-515316 | 200 µg/ml | $316.00 | |||
CCDC18 Antibody (G-5): m-IgGκ BP-HRP Bundle | sc-525000 | 200 µg Ab, 40 µg BP | $354.00 | |||
CCDC18 Antibody (G-5): m-IgG2b BP-HRP Bundle | sc-549204 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCDC18 Antibody (G-5) AC | sc-515316 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCDC18 Antibody (G-5) HRP | sc-515316 HRP | 200 µg/ml | $316.00 | |||
CCDC18 Antibody (G-5) FITC | sc-515316 FITC | 200 µg/ml | $330.00 | |||
CCDC18 Antibody (G-5) PE | sc-515316 PE | 200 µg/ml | $343.00 | |||
CCDC18 Antibody (G-5) Alexa Fluor® 488 | sc-515316 AF488 | 200 µg/ml | $357.00 | |||
CCDC18 Antibody (G-5) Alexa Fluor® 546 | sc-515316 AF546 | 200 µg/ml | $357.00 | |||
CCDC18 Antibody (G-5) Alexa Fluor® 594 | sc-515316 AF594 | 200 µg/ml | $357.00 | |||
CCDC18 Antibody (G-5) Alexa Fluor® 647 | sc-515316 AF647 | 200 µg/ml | $357.00 | |||
CCDC18 Antibody (G-5) Alexa Fluor® 680 | sc-515316 AF680 | 200 µg/ml | $357.00 | |||
CCDC18 Antibody (G-5) Alexa Fluor® 790 | sc-515316 AF790 | 200 µg/ml | $357.00 |