CCDC134 Antibody (B-8): sc-514915
- CCDC134 Antibody (B-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 21-153 mapping within an internal region of CCDC134 of human origin
- recommended for detection of CCDC134 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCDC134 Antibody (B-8) for WB applications. These reagents are now offered in bundles with CCDC134 Antibody (B-8) (see ordering information below).
CCDC134 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects CCDC134 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCDC134, also known as coiled-coil domain containing 134, is a 229 amino acid protein encoded by a gene located on human chromosome 22, which is notable for involvement in various genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2. CCDC134 plays a crucial role in cellular processes, particularly in the formation of coiled-coil structures that facilitate protein-protein interactions, which are essential for maintaining cellular integrity and signaling pathways. Understanding CCDC134 function is important as research may provide insights into molecular mechanisms underlying pathogenesis of diseases associated with chromosome 22, including schizophrenia and certain types of leukemia linked to chromosomal translocations. Anti-CCDC134 antibody (B-8) is an invaluable tool for researchers investigating these critical biological processes and their implications in human health.
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CCDC134 Antibody (B-8) References:
- CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest. | Huang, J., et al. 2012. Histochem Cell Biol. 138: 41-55. PMID: 22644376
- CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway. | Zhong, J., et al. 2013. Mol Cell Biochem. 372: 1-8. PMID: 23070808
- Cytokine-like molecule CCDC134 contributes to CD8⁺ T-cell effector functions in cancer immunotherapy. | Huang, J., et al. 2014. Cancer Res. 74: 5734-45. PMID: 25125657
- Homozygous Loss-of-Function Mutations in CCDC134 Are Responsible for a Severe Form of Osteogenesis Imperfecta. | Dubail, J., et al. 2020. J Bone Miner Res. 35: 1470-1480. PMID: 32181939
- Screening and Analysis of Potential Critical Gene in Acute Myocardial Infarction Based on a miRNA-mRNA Regulatory Network. | Hou, R., et al. 2022. Int J Gen Med. 15: 2847-2860. PMID: 35300139
- miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134. | Huang, Z., et al. 2023. Curr Gene Ther. 23: 60-71. PMID: 36056852
- Assessing type I collagen expression and quality in cellular models of osteogenesis imperfecta. | Udupa, P., et al. 2024. Clin Genet. 105: 329-334. PMID: 38014644
- Regulated N-glycosylation controls chaperone function and receptor trafficking. | Ma, M., et al. 2024. Science. 386: 667-672. PMID: 39509507
- A Novel Homozygous Synonymous Variant in CCDC134 as a Cause of Osteogenesis Imperfecta Type XXII. | Ning, H., et al. 2024. Clin Genet.. PMID: 39623602
- No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. | Blumenthal, A. and Domínguez Cadena, LC. 2025. J Exp Med. 222: PMID: 39907723
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCDC134 Antibody (B-8) | sc-514915 | 200 µg/ml | $322.00 | |||
CCDC134 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-538720 | 200 µg Ab; 10 µg BP | $361.00 | |||
CCDC134 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-536384 | 200 µg Ab; 40 µg BP | $361.00 | |||
CCDC134 Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-545851 | 200 µg Ab; 20 µg BP | $361.00 |