CCDC134 Antibody (E-5): sc-393390
- CCDC134 Antibody (E-5) is a mouse monoclonal IgG1 κ CCDC134 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 215-228 at the C-terminus of CCDC134 of human origin
- CCDC134 Antibody (E-5) is recommended for detection of CCDC134 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CCDC134 Antibody (E-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CCDC134 Antibody (E-5) for WB applications. These reagents are now offered in bundles with CCDC134 Antibody (E-5) (see ordering information below).
CCDC134 Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCDC134 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCDC134 (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. CCDC134, also known as coiled-coil domain containing 134, is a 229 amino acid protein encoded by a gene located on human chromosome 22, which is notable for its association with several genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2. CCDC134 plays a crucial role in cellular processes, particularly in the regulation of cell division and differentiation, making CCDC134 important for understanding developmental biology and potential therapeutic targets in diseases linked to chromosome 22. CCDC134 has been implicated in various signaling pathways, and CCDC134 interactions with specific proteins can influence cellular responses, highlighting CCDC134′s significance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCDC134 Antibody (E-5) References:
- Chromosome 22 workshop report. | Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
- Disease genes and chromosomes: disease maps of the human genome. Chromosome 22. | Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
- Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2. | Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
- Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. | Paylor, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 7729-34. PMID: 16684884
- Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia. | Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. | Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
- Deletion 22q11: spectrum of associated disorders. | Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310
- Amelioration of adjuvant-induced arthritis in CCDC134-overexpressing transgenic mice. | Xia, P., et al. 2017. Biochem Biophys Res Commun. 490: 111-116. PMID: 28571739
- CCDC134 serves a crucial role in embryonic development. | Yu, B., et al. 2018. Int J Mol Med. 41: 381-390. PMID: 29115376
- CCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates. | Huang, Z., et al. 2022. Front Oncol. 12: 858487. PMID: 35311121
- CCDC134 facilitates T cell activation through the regulation of early T cell receptor signaling. | Zhang, T., et al. 2023. Front Immunol. 14: 1133111. PMID: 37234153
- Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings. | Ahronowitz, I., et al. 2007. Hum Mutat. 28: 1-12. PMID: 16983642
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCDC134 Antibody (E-5) | sc-393390 | 200 µg/ml | $316.00 | |||
CCDC134 Antibody (E-5): m-IgG Fc BP-HRP Bundle | sc-527684 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCDC134 Antibody (E-5): m-IgG1 BP-HRP Bundle | sc-533057 | 200 µg Ab; 20 µg BP | $354.00 | |||
CCDC134 Antibody (E-5) AC | sc-393390 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCDC134 Antibody (E-5) HRP | sc-393390 HRP | 200 µg/ml | $316.00 | |||
CCDC134 Antibody (E-5) FITC | sc-393390 FITC | 200 µg/ml | $330.00 | |||
CCDC134 Antibody (E-5) PE | sc-393390 PE | 200 µg/ml | $343.00 | |||
CCDC134 Antibody (E-5) Alexa Fluor® 488 | sc-393390 AF488 | 200 µg/ml | $357.00 | |||
CCDC134 Antibody (E-5) Alexa Fluor® 546 | sc-393390 AF546 | 200 µg/ml | $357.00 | |||
CCDC134 Antibody (E-5) Alexa Fluor® 594 | sc-393390 AF594 | 200 µg/ml | $357.00 | |||
CCDC134 Antibody (E-5) Alexa Fluor® 647 | sc-393390 AF647 | 200 µg/ml | $357.00 | |||
CCDC134 Antibody (E-5) Alexa Fluor® 680 | sc-393390 AF680 | 200 µg/ml | $357.00 | |||
CCDC134 Antibody (E-5) Alexa Fluor® 790 | sc-393390 AF790 | 200 µg/ml | $357.00 | |||
CCDC134 (E-5) Neutralizing Peptide | sc-393390 P | 100 µg/0.5 ml | $68.00 |