Cbl-b Antibody (B-5): sc-376409

Cbl-b Antibody (B-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects Cbl-b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Cbl-b antibody (B-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cbl-b, also known as RING finger protein 56, plays a crucial role in regulating signal transduction pathways by acting as an E3 ubiquitin ligase, which is essential for the ubiquitination and subsequent degradation of target proteins. This function is particularly important in maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to cancer. Cbl-b is predominantly expressed in normal and malignant mammary epithelial cells, as well as various hematopoietic tissues and cell lines, highlighting its significance in both normal physiology and disease states. Cbl-b contains a proline-rich domain, a nuclear localization signal, a C3HC4 zinc finger, and a putative leucine zipper, which are critical for its interactions with other signaling proteins. The ability of Cbl-b to modulate the activity of these proteins underscores its importance in cellular signaling networks and its potential as a therapeutic target in cancer treatment.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cbl-b Antibody (B-5) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Cbl-b Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cbl-b Antibody (B-5) Specifications

Alternate Product Name: CBLB

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 953-982

Epitope Target: Cbl-b

Epitope Species: human

Product Reactivity/Detection: Cbl-b

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Cbl-b Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Cbl-b antibody is Cbl-b Antibody (G-1): sc-8006.