Cbl Antibody (G-12): sc-398282

Cbl Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect the Cbl protein, also known as c-Cbl, CBL proto-oncogene, E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, and RING finger protein 55. Cbl monoclonal antibody (G-12) targets an epitope encompassing amino acids 607-906 at the C-terminus of the human Cbl protein, ensuring precise and reliable binding. The Cbl protein functions as an E3 ubiquitin ligase, playing a critical role in regulating various signaling pathways by ubiquitinating target proteins such as epidermal growth factor receptor (EGFR), Src family kinases, and the insulin receptor. These interactions are essential for controlling processes like cell proliferation, differentiation, and apoptosis, thereby maintaining cellular homeostasis and preventing oncogenic transformations. Anti-Cbl antibody (G-12) exhibits robust reactivity with Cbl proteins from mouse, rat, and human species, making Cbl monoclonal antibody (G-12) suitable for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Cbl antibody (G-12) is available in both non-conjugated form and various conjugated forms, such as horseradish peroxidase (HRP) and Alexa Fluor® variants, providing flexibility for diverse experimental requirements. Cbl (G-12) antibody′s high affinity and specificity make this reagent an invaluable tool for researchers studying the intricate mechanisms of ubiquitination and signal transduction, as well as investigating the molecular underpinnings of diseases like cancer and autoimmune disorders. By enabling the precise detection of Cbl interactions with key signaling proteins, anti-Cbl antibody (G-12) supports advancements in understanding and targeting critical pathways involved in cellular regulation and disease progression.

The preferred Cbl antibody is Cbl Antibody (A-9): sc-1651.