cathepsin W Antibody (1B1): sc-32799

cathepsin W Antibody (1B1) is a mouse monoclonal IgG1 kappa light chain antibody that detects cathepsin W of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-cathepsin W antibody (1B1) is available as a non-conjugated format. Cathepsin W, also known as lymphopain, is part of a unique subgroup of cathepsin proteases, which includes cathepsin F, and is phylogenetically distinct from other human cathepsins. The cathepsin W gene is located on chromosome 11q13.1 and consists of ten exons with introns that vary in size from 81 to 119 base pairs. This protein is specifically expressed in CD8+ T lymphocytes, marking its critical role in the immune response. The expression of cathepsin W begins during the differentiation of thyrocytes into CD8+ T lymphocytes, coinciding with the downregulation of CD4+ receptor expression in thymocytes. Notably, cathepsin W is localized within the rough endoplasmic reticulum in transfected Cos-7 and HeLa cells, which is essential for proper folding and function. Cathepsin W features a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, along with a distinctive 8-amino acid carboxy-terminal extension. Additionally, cathepsin W exhibits an extended loop structure in the second or beta-sheet domain and possesses an extra disulfide bond, which are signature characteristics that contribute to stability and activity. Furthermore, cathepsin W may exist as a dimer, with each monomer linked by a disulfide bond, highlighting complex structural dynamics that are crucial for enzymatic function in immune regulation.

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cathepsin W Antibody (1B1) References:

1. Human cathepsins F and W: A new subgroup of cathepsins.  |  Wex, T., et al. 1999. Biochem Biophys Res Commun. 259: 401-7. PMID: 10362521
2. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.  |  Wex, T., et al. 2001. J Immunol. 167: 2172-8. PMID: 11490002
3. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.  |  Buhling, F., et al. 2002. Biol Chem. 383: 1285-9. PMID: 12437118
4. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.  |  Meinhardt, C., et al. 2004. Biochem Biophys Res Commun. 321: 975-80. PMID: 15358123
5. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes.  |  Linnevers, C., et al. 1997. FEBS Lett. 405: 253-9. PMID: 9108299
6. Genomic structure, chromosomal localization, and expression of human cathepsin W.  |  Wex, T., et al. 1998. Biochem Biophys Res Commun. 248: 255-61. PMID: 9675123
7. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.  |  Brown, J., et al. 1998. Leukemia. 12: 1771-81. PMID: 9823953

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cathepsin W Antibody (1B1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-cathepsin W Antibody (1B1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cathepsin W Antibody (1B1) Specifications

Alternate Product Name: CTSW

Product Clone Name: 1B1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: cathepsin W

Epitope Species: human

Product Reactivity/Detection: cathepsin W

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for cathepsin W Antibody (1B1): N/A