cathepsin H Antibody (5): sc-130310

Cathepsin H Antibody (5) is a mouse monoclonal IgG2a antibody that detects cathepsin H in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Cathepsin H is a lysosomal cysteine proteinase that plays a crucial role in the degradation of lysosomal proteins, which is essential for maintaining cellular homeostasis and regulating various physiological processes. The protein exists as a disulfide-linked heavy and light chain dimer, derived from a single precursor, and belongs to the peptidase C1 protein family, exhibiting both aminopeptidase and endopeptidase activities. Notably, elevated levels of cathepsin H have been associated with the malignant progression of prostate tumors, highlighting its potential as a biomarker for cancer diagnosis and prognosis. The gene encoding cathepsin H produces two transcript variants that result in different isoforms, including a full-length version and a truncated form with a 12-amino acid deletion in the signal peptide region, which are expressed in various prostate tissues and cancer cell lines such as LNCaP, PC-3, and DU-145. Additionally, cathepsin H is involved in the maturation of the biologically active surfactant protein-B peptide, further underscoring its significance in both normal physiology and disease states.

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cathepsin H Antibody (5) References:

1. Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas.  |  del Re, EC., et al. 2000. Br J Cancer. 82: 1317-26. PMID: 10755408
2. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes.  |  Brasch, F., et al. 2002. Am J Respir Cell Mol Biol. 26: 659-70. PMID: 12034564
3. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis.  |  Woischnik, M., et al. 2008. Eur Respir J. 31: 1197-204. PMID: 18216060
4. Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer.  |  Decock, J., et al. 2008. Int J Biol Markers. 23: 161-8. PMID: 18949742
5. Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters.  |  Lu, WD., et al. 2012. J Neurochem. 122: 512-22. PMID: 22582844
6. Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H.  |  Raghav, N. and Singh, M. 2014. Eur J Med Chem. 77: 231-42. PMID: 24642566
7. Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.  |  Oda, K., et al. 2017. Biochem Biophys Res Commun. 483: 541-546. PMID: 27998776
8. Favorable Prognostic Impact of Cathepsin H (CTSH) High Expression in Thyroid Carcinoma.  |  Peng, P., et al. 2021. Int J Gen Med. 14: 5287-5299. PMID: 34522128
9. Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis.  |  Chen, Q., et al. 2023. Int J Mol Sci. 24: PMID: 36982347
10. Human cathepsin H.  |  Schwartz, WN. and Barrett, AJ. 1980. Biochem J. 191: 487-97. PMID: 6165352

The preferred cathepsin H antibody is cathepsin H Antibody (F-7): sc-398527.