cathepsin E Antibody (E-8): sc-166343

Cathepsin E Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects cathepsin E in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Cathepsin E is a nonlysosomal, intracellular proteinase that plays a crucial role in the processing of proteins and peptides, which is essential for maintaining cellular homeostasis and regulating immune responses. Anti-cathepsin E antibody (E-8) participates in antigen processing and presentation, making cathepsin E vital for the adaptive immune system. Additionally, cathepsin E is involved in the maturation of certain proteins, influencing their functionality and stability within the cell. The presence of cathepsin E in various tissues underscores its importance in both physiological and pathological processes, including inflammation and cancer progression. With broad species reactivity and versatility in multiple applications, cathepsin E (E-8) monoclonal antibody serves as an invaluable tool for researchers studying the intricate roles of this protease in health and disease.

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cathepsin E Antibody (E-8) References:

1. Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D.  |  Yasuda, Y., et al. 1999. J Biochem. 125: 1137-43. PMID: 10348917
2. A role for cathepsin E in the processing of mast-cell carboxypeptidase A.  |  Henningsson, F., et al. 2005. J Cell Sci. 118: 2035-42. PMID: 15860733
3. Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.  |  Yanagawa, M., et al. 2007. J Biol Chem. 282: 1851-62. PMID: 17095504
4. Natural cathepsin E deficiency in the immune system of C57BL/6J mice.  |  Tulone, C., et al. 2007. Immunogenetics. 59: 927-35. PMID: 18000662
5. Autocatalytic processing of procathepsin E to cathepsin E and their structural differences.  |  Athauda, SB., et al. 1991. Biochem Biophys Res Commun. 175: 152-8. PMID: 1998500
6. Selective detection of Cathepsin E proteolytic activity.  |  Abd-Elgaliel, WR. and Tung, CH. 2010. Biochim Biophys Acta. 1800: 1002-8. PMID: 20600629
7. The ketogenic diet suppresses the cathepsin E expression induced by kainic acid in the rat brain.  |  Jeong, HJ., et al. 2010. Yonsei Med J. 51: 653-60. PMID: 20635438
8. Cathepsin E, maspin, Plk1, and survivin are promising prognostic protein markers for progression in non-muscle invasive bladder cancer.  |  Fristrup, N., et al. 2012. Am J Pathol. 180: 1824-34. PMID: 22449953
9. Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model.  |  Moreira, J., et al. 2019. Amyloid. 26: 63-64. PMID: 31343320
10. Immunochemical difference between cathepsin D and cathepsin E-like enzyme from rat spleen.  |  Yamamoto, K., et al. 1980. J Biochem. 87: 511-6. PMID: 6766930

The preferred cathepsin E antibody is cathepsin E Antibody (D-8): sc-166500.