cathepsin E Antibody (E-12): sc-166285
- cathepsin E Antibody (E-12) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against amino acids 141-180 mapping within an internal region of cathepsin E of human origin
- recommended for detection of cathepsin E of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for cathepsin E Antibody (E-12) for WB applications. This reagent is now offered in a bundle with cathepsin E Antibody (E-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Cathepsin E (E-12) is a mouse monoclonal IgM antibody that detects cathepsin E in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cathepsin E is a nonlysosomal, intracellular proteinase that plays a crucial role in processing various proteins, including prohormone activation and misfolded protein degradation, which is essential for maintaining cellular homeostasis and preventing potentially toxic protein accumulation. The proper functioning of cathepsin E is vital for various physiological processes, including immune response and cellular signaling, making cathepsin E a significant target for research in diseases where protein misfolding and degradation are implicated. Anti-cathepsin E antibody (E-12) is particularly valuable for studies focused on understanding proteolytic processing mechanisms and their implications in health and disease, providing researchers with a reliable tool for exploring this important enzyme′s intricate roles in cellular metabolism.
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cathepsin E Antibody (E-12) References:
- New functional aspects of cathepsin D and cathepsin E. | Tsukuba, T., et al. 2000. Mol Cells. 10: 601-11. PMID: 11211863
- Emerging functional roles of cathepsin E. | Zaidi, N., et al. 2008. Biochem Biophys Res Commun. 377: 327-330. PMID: 18938134
- Emerging roles of cathepsin E in host defense mechanisms. | Yamamoto, K., et al. 2012. Biochim Biophys Acta. 1824: 105-12. PMID: 21664991
- Cathepsin E deficiency impairs autophagic proteolysis in macrophages. | Tsukuba, T., et al. 2013. PLoS One. 8: e82415. PMID: 24340026
- Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage. | Goto, S., et al. 2014. Mol Hum Reprod. 20: 454-62. PMID: 24464956
- Cathepsin E promotes pulmonary emphysema via mitochondrial fission. | Zhang, X., et al. 2014. Am J Pathol. 184: 2730-41. PMID: 25239563
- Cathepsin E Deficiency Ameliorates Graft-versus-Host Disease and Modifies Dendritic Cell Motility. | Mengwasser, J., et al. 2017. Front Immunol. 8: 203. PMID: 28298913
- Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D. | Stotz, S., et al. 2020. Biochem Biophys Res Commun. 527: 238-241. PMID: 32446374
- TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury. | Zhou, H., et al. 2021. Am J Transplant. 21: 1453-1464. PMID: 32986275
- Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease. | Xie, Z., et al. 2022. Aging Cell. 21: e13565. PMID: 35181976
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cathepsin E Antibody (E-12) | sc-166285 | 200 µg/ml | $316.00 | |||
cathepsin E Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-534746 | 200 µg Ab; 40 µg BP | $354.00 |