cathepsin D Antibody (D-7): sc-377299

cathepsin D Antibody (D-7) is a mouse monoclonal IgM kappa antibody targeting an epitope mapped between amino acids 383-411 at the C-terminus of human cathepsin D, with reactivity in mouse, rat, and human species. Anti-cathepsin D antibody (D-7) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Cathepsin D, also known as CTSD, is a lysosomal aspartyl protease involved in intracellular protein degradation and processing protein precursors into bioactive peptides. Cathepsin D plays a critical role in cellular metabolism, autophagy, and apoptosis, making cathepsin D essential for maintaining cellular homeostasis. As a zymogen, cathepsin D undergoes proteolytic cleavage to become active, and this process is tightly regulated to ensure proper function within the acidic lysosomal environment. Cathepsin D activity influences key biological processes, including tumor progression, where cathepsin D can contribute to cancer cell invasion and metastasis, as well as neurodegenerative diseases. Cathepsin D interacts with proteins involved in stress response and apoptotic pathways, further emphasizing cathepsin D′s regulatory role. Expression of cathepsin D is regulated by transcription factors such as Sp1 and AP-2, which bind to cathepsin D′s promoter region in response to cellular demands. Anti-cathepsin D antibody (D-7) is an invaluable tool for exploring the functional importance of cathepsin D in health and disease.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cathepsin D Antibody (D-7) has 49 citations in a variety of scientific publications.

Primary antibodies like Anti-cathepsin D Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cathepsin D Antibody (D-7) Specifications

Alternate Product Name: CTSD

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 383-411

Epitope Target: cathepsin D

Epitope Species: human

Product Reactivity/Detection: cathepsin D

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 49 citations in various scientific publications

Available Conjugates/Forms for cathepsin D Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred cathepsin D antibody is cathepsin D Antibody (C-5): sc-377124.