cathepsin D Antibody (4G2): sc-53927

Cathepsin D Antibody (4G2) is a mouse monoclonal IgG2b antibody raised against amino acids 21-412 of human cathepsin D, with validated applications in western blotting (WB) and immunoprecipitation (IP). Cathepsin D, also known as CTSD, is an aspartyl protease predominantly localized in the lysosomes, where CTSD functions in the degradation of proteins and peptides within the acidic lysosomal environment. This localization is critical for maintaining cellular homeostasis, as cathepsin D participates in autophagy, apoptosis, and the turnover of intracellular proteins. Synthesized as an inactive precursor, cathepsin D undergoes proteolytic cleavage to produce active forms that mediate enzymatic activity. Beyond degradative roles, cathepsin D processes protein precursors to release bioactive peptides that regulate various physiological processes. Dysregulation of cathepsin D has been implicated in diseases such as cancer, where cathepsin D can influence tumor growth, invasion, and metastasis. The gene encoding cathepsin D is regulated by transcription factors such as Sp1 and AP-2, which govern expression in response to cellular needs. Anti-cathepsin D antibody (4G2) is a powerful tool for studying cathepsin D′s role in lysosomal function, cellular metabolism, and pathological conditions.

The preferred cathepsin D antibody is cathepsin D Antibody (C-5): sc-377124.