cathepsin D Antibody (49): sc-136282

cathepsin D Antibody (49) is a mouse monoclonal IgG2a antibody with validated applications in western blotting (WB) and immunoprecipitation (IP) and reactivity to human proteins. Cathepsin D, also referred to as CTSD, is an aspartyl protease that is predominantly located in the lysosomes, where CTSD plays a central role in protein degradation and turnover. Structurally, cathepsin D is synthesized as a precursor protein that undergoes proteolytic cleavage to form an active enzyme, consisting of a heavy and light chain linked by disulfide bonds. This structure is essential for CTSD stability and enzymatic function within the acidic lysosomal environment. In addition to degrading intracellular proteins, cathepsin D is involved in processing specific protein precursors to generate bioactive peptides that regulate processes such as apoptosis, cell growth, and immune responses. CTSD activity is regulated through structure and localization, with disruptions in these processes linked to pathological conditions, including cancer and neurodegenerative diseases. The gene encoding cathepsin D contains regulatory elements such as Sp1 and AP-2 binding sites, which control CTSD expression in response to cellular signals. Anti-cathepsin D antibody (49) is an effective tool for studying the structural and functional roles of cathepsin D in health and disease.

The preferred cathepsin D antibody is cathepsin D Antibody (C-5): sc-377124.