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CASZ1 Antibody (B-11): sc-398303

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Datasheets
  • CASZ1 Antibody (B-11) is a mouse monoclonal IgG2b κ CASZ1 antibody, cited in 5 publications, provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 913-926 within an internal region of CASZ1 of human origin
  • CASZ1 Antibody (B-11) is recommended for detection of CASZ1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • Anti-CASZ1 Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • TransCruz reagent for ChIP application (sc-398303 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CASZ1 Antibody (B-11) for WB and IHC(P) applications. These reagents are now offered in bundles with CASZ1 Antibody (B-11) (see ordering information below).

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CASZ1 Antibody (B-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects CASZ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CASZ1 Antibody (B-11) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CASZ1, also known as castor zinc finger 1, CST, SRG, or ZNF693, is a 1,759 amino acid transcription factor that plays a crucial role in regulating gene expression, particularly during development and cellular differentiation. Nuclear localization and eight C2H2-type zinc fingers are essential for DNA binding and interaction with other transcriptional regulators. CASZ1 is expressed in various tissues, including stomach, lung, testis, pancreas, heart, skeletal muscle, and small intestine, and exists as multiple alternatively spliced isoforms, contributing to diverse regulatory roles. Human CASZ1 shares over 85% sequence homology with mouse CASZ1, indicating conserved function across species. CASZ1 gene is located on human chromosome 1, a region associated with numerous disease-related genes, including those implicated in familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia, and Usher syndrome. Aberrations in chromosome 1 have been linked to various cancers, such as head and neck cancer, malignant melanoma, and multiple myeloma, underscoring CASZ1′s importance in normal physiology and disease states.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

CASZ1 Antibody (B-11) References:

  1. Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis.  |  Yuan, ZR., et al. 2005. Cancer Res. 65: 10716-24. PMID: 16322216
  2. Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation.  |  Liu, Z., et al. 2006. Biochem Biophys Res Commun. 344: 834-44. PMID: 16631614
  3. Association analysis of chromosome 1 migraine candidate genes.  |  Fernandez, F., et al. 2007. BMC Med Genet. 8: 57. PMID: 17727731
  4. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours.  |  Carén, H., et al. 2007. Br J Cancer. 97: 1416-24. PMID: 17940511
  5. CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity.  |  Yokota, K., et al. 2023. Hypertens Res. 46: 417-420. PMID: 36522424
  6. CASZ1: Current Implications in Cardiovascular Diseases and Cancers.  |  Jian, H. and Poetsch, A. 2023. Biomedicines. 11: PMID: 37509718
  7. Role of the CASZ1 transcription factor in tissue development and disease.  |  Liu, T., et al. 2023. Eur J Med Res. 28: 562. PMID: 38053207
  8. CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.  |  Cardoso, BA., et al. 2024. Haematologica. 109: 1713-1725. PMID: 38058200
  9. CASZ1 Is Essential for Skin Epidermal Terminal Differentiation.  |  Droll, SH., et al. 2024. J Invest Dermatol. 144: 2029-2038. PMID: 38458428
  10. Epigenetic modification of Castor zinc finger 1 (CASZ1) is associated with tumor microenvironments and prognosis of clear cell renal cell carcinoma.  |  Li, F., et al. 2024. Int J Surg.. PMID: 39235847

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CASZ1 Antibody (B-11)

sc-398303
200 µg/ml
$316.00

CASZ1 Antibody (B-11): m-IgG Fc BP-HRP Bundle

sc-530750
200 µg Ab; 10 µg BP
$354.00

CASZ1 Antibody (B-11): m-IgGκ BP-HRP Bundle

sc-524285
200 µg Ab, 40 µg BP
$354.00

CASZ1 Antibody (B-11): m-IgG2b BP-HRP Bundle

sc-550220
200 µg Ab; 10 µg BP
$354.00

CASZ1 Antibody (B-11) X

sc-398303 X
200 µg/0.1 ml
$316.00

CASZ1 Antibody (B-11) AC

sc-398303 AC
500 µg/ml, 25% agarose
$416.00

CASZ1 Antibody (B-11) HRP

sc-398303 HRP
200 µg/ml
$316.00

CASZ1 Antibody (B-11) FITC

sc-398303 FITC
200 µg/ml
$330.00

CASZ1 Antibody (B-11) PE

sc-398303 PE
200 µg/ml
$343.00

CASZ1 Antibody (B-11) Alexa Fluor® 488

sc-398303 AF488
200 µg/ml
$357.00

CASZ1 Antibody (B-11) Alexa Fluor® 546

sc-398303 AF546
200 µg/ml
$357.00

CASZ1 Antibody (B-11) Alexa Fluor® 594

sc-398303 AF594
200 µg/ml
$357.00

CASZ1 Antibody (B-11) Alexa Fluor® 647

sc-398303 AF647
200 µg/ml
$357.00

CASZ1 Antibody (B-11) Alexa Fluor® 680

sc-398303 AF680
200 µg/ml
$357.00

CASZ1 Antibody (B-11) Alexa Fluor® 790

sc-398303 AF790
200 µg/ml
$357.00

CASZ1 (B-11) Neutralizing Peptide

sc-398303 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-398303 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Exceptional immunofluorescence cytoplasmicExceptional immunofluorescence cytoplasmic, nucleolar and nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-05-16
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CASZ1 Antibody (B-11) is rated 5.0 out of 5 by 2.
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