CASZ1 Antibody (B-11): sc-398303

CASZ1 Antibody (B-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects CASZ1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CASZ1 Antibody (B-11) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CASZ1, also known as castor zinc finger 1, CST, SRG, or ZNF693, is a 1,759 amino acid transcription factor that plays a crucial role in regulating gene expression, particularly during development and cellular differentiation. Nuclear localization and eight C2H2-type zinc fingers are essential for DNA binding and interaction with other transcriptional regulators. CASZ1 is expressed in various tissues, including stomach, lung, testis, pancreas, heart, skeletal muscle, and small intestine, and exists as multiple alternatively spliced isoforms, contributing to diverse regulatory roles. Human CASZ1 shares over 85% sequence homology with mouse CASZ1, indicating conserved function across species. CASZ1 gene is located on human chromosome 1, a region associated with numerous disease-related genes, including those implicated in familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia, and Usher syndrome. Aberrations in chromosome 1 have been linked to various cancers, such as head and neck cancer, malignant melanoma, and multiple myeloma, underscoring CASZ1′s importance in normal physiology and disease states.

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CASZ1 Antibody (B-11) References:

1. Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis.  |  Yuan, ZR., et al. 2005. Cancer Res. 65: 10716-24. PMID: 16322216
2. Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation.  |  Liu, Z., et al. 2006. Biochem Biophys Res Commun. 344: 834-44. PMID: 16631614
3. Association analysis of chromosome 1 migraine candidate genes.  |  Fernandez, F., et al. 2007. BMC Med Genet. 8: 57. PMID: 17727731
4. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours.  |  Carén, H., et al. 2007. Br J Cancer. 97: 1416-24. PMID: 17940511
5. CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity.  |  Yokota, K., et al. 2023. Hypertens Res. 46: 417-420. PMID: 36522424
6. CASZ1: Current Implications in Cardiovascular Diseases and Cancers.  |  Jian, H. and Poetsch, A. 2023. Biomedicines. 11: PMID: 37509718
7. Role of the CASZ1 transcription factor in tissue development and disease.  |  Liu, T., et al. 2023. Eur J Med Res. 28: 562. PMID: 38053207
8. CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.  |  Cardoso, BA., et al. 2024. Haematologica. 109: 1713-1725. PMID: 38058200
9. CASZ1 Is Essential for Skin Epidermal Terminal Differentiation.  |  Droll, SH., et al. 2024. J Invest Dermatol. 144: 2029-2038. PMID: 38458428
10. Epigenetic modification of Castor zinc finger 1 (CASZ1) is associated with tumor microenvironments and prognosis of clear cell renal cell carcinoma.  |  Li, F., et al. 2024. Int J Surg.. PMID: 39235847

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CASZ1 Antibody (B-11) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CASZ1 Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CASZ1 Antibody (B-11) Specifications

Alternate Product Name: CASZ1

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 913-926

Epitope Target: CASZ1

Epitope Species: human

Product Reactivity/Detection: CASZ1 isoforms 1 and 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CASZ1 Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent