CASPR2 Antibody (H-10): sc-398454
- CASPR2 Antibody (H-10) is a mouse monoclonal IgG2b κ CASPR2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 461-560 mapping within an N-terminal extracellular domain of CASPR2 of human origin
- CASPR2 Antibody (H-10) is recommended for detection of CASPR2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CASPR2 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CASPR2 Antibody (H-10) for WB applications. These reagents are now offered in bundles with CASPR2 Antibody (H-10) (see ordering information below).
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CASPR2 Antibody (H-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects CASPR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CASPR2 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CASPR2, also known as contactin-associated protein 2, is a crucial transmembrane glycoprotein belonging to the neurexin superfamily, predominantly found in the juxtaparanodal regions of myelinated axons. CASPR2 precise localization is vital for proper nervous system functioning, playing a significant role in clustering voltage-gated potassium channels, specifically Kv1.1 and Kv1.2, which are essential for maintaining rapid action potential propagation along myelinated fibers. CASPR2 interaction with these potassium channels facilitates efficient signal transmission and contributes to axonal membrane structural integrity, highlighting CASPR2 importance in neuronal communication and overall nervous system health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CASPR2 Antibody (H-10) References:
- Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. | Poliak, S., et al. 1999. Neuron. 24: 1037-47. PMID: 10624965
- Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr. | Arroyo, EJ., et al. 1999. J Neurocytol. 28: 333-47. PMID: 10739575
- The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (caspr). | Faivre-Sarrailh, C., et al. 2000. J Cell Biol. 149: 491-502. PMID: 10769038
- Axon-glia interactions: building a smart nerve fiber. | Waxman, SG. 1997. Curr Biol. 7: R406-10. PMID: 9210363
- The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination. | Einheber, S., et al. 1997. J Cell Biol. 139: 1495-506. PMID: 9396755
- Neurexins: three genes and 1001 products. | Missler, M. and Südhof, TC. 1998. Trends Genet. 14: 20-6. PMID: 9448462
- Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia. | Bellen, HJ., et al. 1998. Trends Neurosci. 21: 444-9. PMID: 9786343
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CASPR2 Antibody (H-10) | sc-398454 | 200 µg/ml | $322.00 | |||
CASPR2 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-530804 | 200 µg Ab; 10 µg BP | $361.00 | |||
CASPR2 Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-524348 | 200 µg Ab, 40 µg BP | $361.00 | |||
CASPR2 Antibody (H-10): m-IgG2b BP-HRP Bundle | sc-550230 | 200 µg Ab; 10 µg BP | $361.00 | |||
CASPR2 Antibody (H-10) AC | sc-398454 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CASPR2 Antibody (H-10) HRP | sc-398454 HRP | 200 µg/ml | $322.00 | |||
CASPR2 Antibody (H-10) FITC | sc-398454 FITC | 200 µg/ml | $336.00 | |||
CASPR2 Antibody (H-10) PE | sc-398454 PE | 200 µg/ml | $349.00 | |||
CASPR2 Antibody (H-10) Alexa Fluor® 488 | sc-398454 AF488 | 200 µg/ml | $364.00 | |||
CASPR2 Antibody (H-10) Alexa Fluor® 546 | sc-398454 AF546 | 200 µg/ml | $364.00 | |||
CASPR2 Antibody (H-10) Alexa Fluor® 594 | sc-398454 AF594 | 200 µg/ml | $364.00 | |||
CASPR2 Antibody (H-10) Alexa Fluor® 647 | sc-398454 AF647 | 200 µg/ml | $364.00 | |||
CASPR2 Antibody (H-10) Alexa Fluor® 680 | sc-398454 AF680 | 200 µg/ml | $364.00 | |||
CASPR2 Antibody (H-10) Alexa Fluor® 790 | sc-398454 AF790 | 200 µg/ml | $364.00 |