caspase-11 Antibody (17D9): sc-56038
- caspase-11 Antibody (17D9) is a rat monoclonal IgG2a caspase-11 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against recombinant caspase-11 of mouse origin
- recommended for detection of caspase-11 of mouse and rat origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for caspase-11 Antibody (17D9). This work is in progress.
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Caspase-11 Antibody (17D9) is a rat monoclonal IgG2a antibody that detects caspase-11 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-caspase-11 antibody (17D9) is available as a non-conjugated format. Caspase-11 is primarily located in the cytosol of immune cells, where caspase-11 plays a pivotal role in inflammatory response and cell death pathways. Caspase-11 localization allows for rapid activation in response to cytosolic danger signals, such as bacterial lipopolysaccharides, which can trigger inflammatory cell death known as pyroptosis. This process is essential for host defense against infections, as caspase-11 helps eliminate infected cells and release pro-inflammatory cytokines, thereby recruiting additional immune cells to the site of infection. Dysregulation of caspase-11 activity has been implicated in various inflammatory diseases, making caspase-11 a significant target for therapeutic intervention. Understanding caspase-11 function and localization is vital for developing strategies to modulate caspase-11 activity in disease contexts, particularly in conditions characterized by excessive inflammation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-11 Antibody (17D9) References:
- The most unkindest cut of all: on the multiple roles of mammalian caspases. | Fadeel, B., et al. 2000. Leukemia. 14: 1514-25. PMID: 10942252
- Noncaspase proteases in apoptosis. | Johnson, DE. 2000. Leukemia. 14: 1695-703. PMID: 10995018
- Caspase pathways, neuronal apoptosis, and CNS injury. | Eldadah, BA. and Faden, AI. 2000. J Neurotrauma. 17: 811-29. PMID: 11063050
- Proteases for cell suicide: functions and regulation of caspases. | Chang, HY. and Yang, X. 2000. Microbiol Mol Biol Rev. 64: 821-46. PMID: 11104820
- Caspases: key players in programmed cell death. | Grütter, MG. 2000. Curr Opin Struct Biol. 10: 649-55. PMID: 11114501
- Signaling for the caspases: their role in prostate cell apoptosis. | Coffey, RN., et al. 2001. J Urol. 165: 5-14. PMID: 11125352
- Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. | Hisahara, S., et al. 2001. J Exp Med. 193: 111-22. PMID: 11136825
- Caspase mRNA expression in a rat model of focal cerebral ischemia. | Harrison, DC., et al. 2001. Brain Res Mol Brain Res. 89: 133-46. PMID: 11311984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-11 Antibody (17D9) | sc-56038 | 200 µg/ml | $322.00 |