CASKIN2 Antibody (D-9): sc-377512
- CASKIN2 Antibody (D-9) is a mouse monoclonal IgG2b κ CASKIN2 antibody provided at 200 µg/ml
- raised against amino acids 338-515 mapping within an internal region of CASKIN2 of human origin
- CASKIN2 Antibody (D-9) is recommended for detection of CASKIN2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CASKIN2 Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CASKIN2 Antibody (D-9) for WB applications. These reagents are now offered in bundles with CASKIN2 Antibody (D-9) (see ordering information below).
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CASKIN2 Antibody (D-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects CASKIN2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CASKIN2 (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CASKIN2, also known as CASK interacting protein 2 or ANKS5B, is a 1,202 amino acid protein primarily localized in the cytoplasm and features one SH3 domain, two SAM domains, and six ANK repeats. CASKIN2 is expressed ubiquitously, with highest levels found in fetal and adult liver tissues, and plays a crucial role in cellular signaling by interacting with CASK, thereby linking to various downstream effectors. CASKIN2 is involved in regulating synaptic function and neuronal signaling, which are vital for proper brain function and development. CASKIN2 gene is located on human chromosome 17, a region comprising over 2.5% of the human genome and associated with key tumor suppressor genes such as p53 and BRCA1, both critical in maintaining genomic stability and preventing cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CASKIN2 Antibody (D-9) References:
- CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. | Tabuchi, K., et al. 2002. J Neurosci. 22: 4264-73. PMID: 12040031
- BLIMP1 regulates cell growth through repression of p53 transcription. | Yan, J., et al. 2007. Proc Natl Acad Sci U S A. 104: 1841-6. PMID: 17264218
- Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. | Sauermann, M., et al. 2008. Oncogene. 27: 1320-6. PMID: 17724469
- Susceptibility to breast cancer: hereditary syndromes and low penetrance genes. | Nusbaum, R., et al. Breast Dis. 27: 21-50. PMID: 17917139
- The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. | Ropolo, A., et al. 2007. J Biol Chem. 282: 37124-33. PMID: 17940279
- Breast cancer risk among male BRCA1 and BRCA2 mutation carriers. | Tai, YC., et al. 2007. J Natl Cancer Inst. 99: 1811-4. PMID: 18042939
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CASKIN2 Antibody (D-9) | sc-377512 | 200 µg/ml | $316.00 | |||
CASKIN2 Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-523352 | 200 µg Ab, 40 µg BP | $354.00 | |||
CASKIN2 Antibody (D-9): m-IgG2b BP-HRP Bundle | sc-549111 | 200 µg Ab; 10 µg BP | $354.00 | |||
CASKIN2 Antibody (D-9) AC | sc-377512 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CASKIN2 Antibody (D-9) HRP | sc-377512 HRP | 200 µg/ml | $316.00 | |||
CASKIN2 Antibody (D-9) FITC | sc-377512 FITC | 200 µg/ml | $330.00 | |||
CASKIN2 Antibody (D-9) PE | sc-377512 PE | 200 µg/ml | $343.00 | |||
CASKIN2 Antibody (D-9) Alexa Fluor® 488 | sc-377512 AF488 | 200 µg/ml | $357.00 | |||
CASKIN2 Antibody (D-9) Alexa Fluor® 546 | sc-377512 AF546 | 200 µg/ml | $357.00 | |||
CASKIN2 Antibody (D-9) Alexa Fluor® 594 | sc-377512 AF594 | 200 µg/ml | $357.00 | |||
CASKIN2 Antibody (D-9) Alexa Fluor® 647 | sc-377512 AF647 | 200 µg/ml | $357.00 | |||
CASKIN2 Antibody (D-9) Alexa Fluor® 680 | sc-377512 AF680 | 200 µg/ml | $357.00 | |||
CASKIN2 Antibody (D-9) Alexa Fluor® 790 | sc-377512 AF790 | 200 µg/ml | $357.00 |