CASKIN2 Activators
CASKIN2 activators encompass a diverse group of compounds that enhance the functional activity of CASKIN2 via various cellular and biochemical pathways. For instance, Forskolin and PDE4 inhibitor Rolipram act by increasing intracellular cAMP levels, which then activate PKA. PKA-mediated signaling plays a pivotal role in modulating CASKIN2 activity. Similarly, by inhibiting protein kinases that negatively regulate CASKIN2, compounds like Epigallocatechin Gallate (EGCG) can enhance the signaling cascade associated with CASKIN2, leading to its functional activity enhancement. In contrast, AGS3 inhibitors facilitate G protein-coupled receptor signaling, a pathway where CASKIN2 is a critical player, thus promoting its activity. Moreover, compounds such as D-cycloserine and BDNFMimetic 7,8-Dihydroxyflavone activate neurotransmitter receptors like NMDA and TrkB, respectively, which indirectly upregulate CASKIN2 activity by modulating synaptic transmission and plasticity, areas where CASKIN2 is inherently involved.
On the other hand, chemicals that affect cellular structures and metabolic states also play a role in the activation of CASKIN2. Paclitaxel, for example, stabilizes microtubules, which can lead to the enhancement of signaling pathways that indirectly involve CASKIN2 due to its role in cytoskeletal organization. Autophagy inducers like spermidine may influence neuronal survival and synaptic plasticity, indirectly enhancing CASKIN2's functional activity. Nicotinamide Mononucleotide (NMN) enhances cellular metabolism and energy production, which is crucial for maintaining the neuronal activity where CASKIN2 is engaged. L-Theanine's modulation of glutamatergic signaling provides another avenue for the potential enhancement of CASKIN2's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP) in the cell. CASKIN2 is known to be modulated via cAMP-dependent protein kinase A (PKA) signaling, thereby enhancing its function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), preventing the breakdown of cAMP. Elevated cAMP levels can stimulate PKA activity, which in turn can increase CASKIN2 activity through phosphorylation and regulation of associated signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit the activity of certain protein kinases. By inhibiting negative regulatory kinases, EGCG could enhance the activity of CASKIN2 through disinhibition of its signaling cascade. | ||||||
D-Cycloserine | 68-41-7 | sc-221470 sc-221470A sc-221470B sc-221470C | 200 mg 1 g 5 g 25 g | $27.00 $75.00 $139.00 $520.00 | 4 | |
D-cycloserine partially activates the NMDA receptors, which can lead to changes in synaptic plasticity. CASKIN2, involved in synaptic organization, can be indirectly activated by the downstream effects of NMDA receptor activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK can lead to the phosphorylation of various substrates, including those that may interact with CASKIN2, thus promoting its activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and as CASKIN2 is involved in cytoskeletal organization, this stabilization can lead to enhanced signaling through pathways where CASKIN2 is indirectly implicated. | ||||||
7,8-Dihydroxyflavone | 38183-03-8 | sc-278634 | 100 mg | $51.00 | 2 | |
This compound mimics Brain-Derived Neurotrophic Factor (BDNF), which can activate TrkB receptors. Through TrkB receptor signaling, the activity of CASKIN2 can be enhanced due to its role in synaptic function and plasticity. | ||||||
L-Theanine | 3081-61-6 | sc-204787 sc-204787A | 1 g 5 g | $57.00 $139.00 | 1 | |
L-Theanine is known to modulate neurotransmitter activity, including glutamate. By influencing glutamatergic signaling, L-Theanine may contribute to the regulation and enhancement of CASKIN2 activity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine has been shown to induce autophagy. Enhanced autophagic processes can affect synaptic plasticity and neuron survival, processes in which CASKIN2 plays a role, potentially increasing its functional activity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor for NAD+ biosynthesis, which is pivotal in cellular metabolism and energy production. Since CASKIN2 is involved in neuronal activity, increased energy metabolism may indirectly enhance the activity of CASKIN2. | ||||||