casein kinase IIα Antibody (F-10): sc-365763

casein kinase IIα Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect casein kinase IIα (CK2α), also known as CSNK2A1, across multiple species including mouse, rat, human, and avian, as well as additional species such as canine, bovine, and porcine. anti-CK2α antibody (F-10) is raised against amino acids 1-320 of human CK2α, ensuring strong reactivity with both CK2α and its isoform CK2α′ (CSNK2A2) in applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CK2α is a serine/threonine protein kinase that plays a pivotal role in numerous cellular processes such as cell cycle regulation, DNA replication and repair, apoptosis, and transcriptional control. Structurally, CK2α typically forms a tetrameric complex with regulatory β subunits, which is essential for its catalytic activity and substrate specificity. Post-translational modifications, particularly autophosphorylation of CK2α, are crucial for regulating kinase activity and interactions with other proteins, thereby influencing diverse signaling pathways involved in cellular homeostasis and disease progression. CK2α′s ability to phosphorylate over a hundred substrates, including nuclear oncoproteins and transcription factors, underscores its significance in maintaining cellular function and its implication in various pathologies, especially cancer. CK2α (F-10) monoclonal antibody provides researchers with a reliable tool to study the functional dynamics and regulatory mechanisms of CK2α in both normal and diseased states, facilitating advancements in understanding cellular biology and developing targeted therapies.

The preferred casein kinase IIα antibody is casein kinase IIα Antibody (1AD9): sc-12738.