casein kinase IIα Antibody (E-7): sc-373894

casein kinase IIα Antibody (E-7) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect casein kinase IIα (CK2α), also known as CSNK2A1, across multiple species including mouse, rat, human, canine, bovine, porcine, and avian. Anti-casein kinase IIα antibody (E-7) targets a unique epitope mapping between amino acids 2-27 at the N-terminus of human CK2α, ensuring precise and reliable performance in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CK2α is a crucial serine/threonine protein kinase involved in regulating a myriad of cellular processes, including cell cycle progression, DNA replication and repair, apoptosis, and transcriptional regulation. CK2α plays a significant role in maintaining cellular homeostasis and is essential for normal cellular function. Structurally, CK2α typically forms a tetrameric complex with regulatory β subunits, which is vital for catalytic activity and substrate specificity. CK2α interacts with a variety of important proteins such as p53, NF-κB, PTEN, and several transcription factors, facilitating key signaling pathways that influence gene expression and cellular responses. CK2α′s ability to phosphorylate over a hundred different substrates highlights extensive involvement in cellular function and potential as a therapeutic target, particularly in cancer research where CK2α dysregulation is often linked to tumor progression and resistance to apoptosis. Anti-casein kinase IIα antibody (E-7) enables researchers to explore intricate mechanisms of CK2α-mediated signaling pathways, advancing understanding of roles in both normal physiology and various disease states, and supporting development of targeted therapies in biomedical research.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-casein kinase IIα Antibody (E-7) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-casein kinase IIα Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

casein kinase IIα Antibody (E-7) Specifications

Alternate Product Name: casein kinase 2 alpha

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 2-27

Epitope Target: casein kinase IIα

Epitope Species: human

Product Reactivity/Detection: casein kinase IIα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for casein kinase IIα Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred casein kinase IIα antibody is casein kinase IIα Antibody (1AD9): sc-12738.