casein kinase Iγ2 Antibody (F-10): sc-390970

Casein kinase Iγ2 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects casein kinase I gamma 2 (CSNK1G2) by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CSNK1G2 antibody (F-10) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CSNK1G2 plays a crucial role in cellular signaling pathways, particularly in regulating circadian rhythms and cell cycle progression. CSNK1G2′s ability to phosphorylate serine and threonine residues on target proteins is essential for modulating various cellular processes, including gene expression and protein stability. Dysregulation of CSNK1G2 has been linked to several diseases, including cancer and neurodegenerative disorders, highlighting CSNK1G2′s importance as a potential therapeutic target. The casein kinase I family, which includes other isoforms such as casein kinase Iα, Iδ, and Iε, is known for involvement in critical cellular functions, making CSNK1G2 particularly relevant in understanding both normal physiology and disease mechanisms.

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casein kinase Iγ2 Antibody (F-10) References:

1. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.  |  Mishra, SK., et al. 2004. Oncogene. 23: 4422-9. PMID: 15077195
2. SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.  |  Shirogane, T., et al. 2005. J Biol Chem. 280: 26863-72. PMID: 15917222
3. Casein kinase I and II--multipotential serine protein kinases: structure, function, and regulation.  |  Tuazon, PT. and Traugh, JA. 1991. Adv Second Messenger Phosphoprotein Res. 23: 123-64. PMID: 1997039
4. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.  |  Lozeman, FJ., et al. 1990. Biochemistry. 29: 8436-47. PMID: 2174700
5. Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway.  |  Li, X., et al. 2018. Theranostics. 8: 3643-3653. PMID: 30026872
6. CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.  |  Nguyen Hoang, AT., et al. 2021. PLoS One. 16: e0246264. PMID: 33861751
7. Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels.  |  Bustos, VH., et al. 2024. ACS Chem Biol. 19: 37-47. PMID: 38079390
8. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes.  |  Zhai, L., et al. 1995. J Biol Chem. 270: 12717-24. PMID: 7759525
9. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.  |  Fish, KJ., et al. 1995. J Biol Chem. 270: 14875-83. PMID: 7797465
10. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.  |  Allende, JE. and Allende, CC. 1995. FASEB J. 9: 313-23. PMID: 7896000
11. Casein kinase II in signal transduction and cell cycle regulation.  |  Litchfield, DW. and Lüscher, B. 1993. Mol Cell Biochem. 127-128: 187-99. PMID: 7935350
12. Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.  |  Graves, PR., et al. 1993. J Biol Chem. 268: 6394-401. PMID: 8454611

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-casein kinase Iγ2 Antibody (F-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-casein kinase Iγ2 Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

casein kinase Iγ2 Antibody (F-10) Specifications

Alternate Product Name: CSNK1G2

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-40

Epitope Target: casein kinase IΓ2

Epitope Species: human

Product Reactivity/Detection: casein kinase Iγ2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for casein kinase Iγ2 Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred casein kinase Iγ1 antibody is casein kinase Iγ1 Antibody (A-6): sc-133206.