casein kinase Iγ1 Antibody (A-6): sc-133206

Casein kinase Iγ1 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects casein kinase I gamma 1 (CSNK1G1) of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CSNK1G1 antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CSNK1G1 plays a crucial role in cellular signaling pathways, particularly in the regulation of circadian rhythms and cell cycle progression. CSNK1G1 is primarily located in the cytoplasm and nucleus, where CSNK1G1 participates in the phosphorylation of various substrates, influencing processes such as gene expression and cellular response to stress. The ability of CSNK1G1 to modulate these critical cellular functions underscores CSNK1G1′s importance in maintaining cellular homeostasis and potential implications in diseases such as cancer and neurodegenerative disorders. With versatile applications and significance in cellular regulation, CSNK1G1 (A-6) monoclonal antibody is an essential tool for researchers studying the intricate mechanisms of cell signaling and function.

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casein kinase Iγ1 Antibody (A-6) References:

1. Casein kinase I in the mammalian circadian clock.  |  Eide, EJ., et al. 2005. Methods Enzymol. 393: 408-18. PMID: 15817302
2. Casein kinase I and II--multipotential serine protein kinases: structure, function, and regulation.  |  Tuazon, PT. and Traugh, JA. 1991. Adv Second Messenger Phosphoprotein Res. 23: 123-64. PMID: 1997039
3. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.  |  Lozeman, FJ., et al. 1990. Biochemistry. 29: 8436-47. PMID: 2174700
4. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.  |  Krönke, J., et al. 2015. Nature. 523: 183-188. PMID: 26131937
5. Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.  |  Mullin, NP., et al. 2021. FEBS Lett. 595: 14-25. PMID: 33107035
6. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.  |  Bourdenx, M., et al. 2021. Cell. 184: 2696-2714.e25. PMID: 33891876
7. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes.  |  Zhai, L., et al. 1995. J Biol Chem. 270: 12717-24. PMID: 7759525
8. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.  |  Fish, KJ., et al. 1995. J Biol Chem. 270: 14875-83. PMID: 7797465
9. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.  |  Allende, JE. and Allende, CC. 1995. FASEB J. 9: 313-23. PMID: 7896000
10. Casein kinase II in signal transduction and cell cycle regulation.  |  Litchfield, DW. and Lüscher, B. 1993. Mol Cell Biochem. 127-128: 187-99. PMID: 7935350
11. Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.  |  Graves, PR., et al. 1993. J Biol Chem. 268: 6394-401. PMID: 8454611
12. A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte.  |  Gross, SD., et al. 1997. J Cell Sci. 110 (Pt 24): 3083-90. PMID: 9365278

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-casein kinase Iγ1 Antibody (A-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-casein kinase Iγ1 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

casein kinase Iγ1 Antibody (A-6) Specifications

Alternate Product Name: CSNK1G1

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-70

Epitope Target: casein kinase IΓ1

Epitope Species: rat

Product Reactivity/Detection: casein kinase Iγ1, casein kinase Iγ2 and casein kinase Iγ3

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for casein kinase Iγ1 Antibody (A-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin