casein kinase Iδ Antibody (E-10): sc-55554
- casein kinase Iδ Antibody (E-10) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 296-355 mapping near the C-terminus of casein kinase Iδ of human origin
- recommended for detection of casein kinase Iδ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and bovine
- See casein kinase Iδ (C-8): sc-55553 for casein kinase Iδ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for casein kinase Iδ Antibody (E-10) for WB applications. These reagents are now offered in bundles with casein kinase Iδ Antibody (E-10) (see ordering information below).
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casein kinase Iδ Antibody (E-10) is a mouse monoclonal IgG2a antibody that detects casein kinase Iδ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Casein kinase Iδ plays a crucial role in various cellular processes, particularly in the regulation of circadian rhythms and cell cycle progression, making casein kinase Iδ essential for maintaining cellular homeostasis and responding to environmental cues. Casein kinase Iδ is primarily located in the cytoplasm and nucleus, where casein kinase Iδ participates in signaling pathways that influence gene expression and cellular proliferation. The ability of casein kinase Iδ to modulate these pathways underscores casein kinase Iδ′s importance in both normal cellular function and disease states, including cancer, where dysregulation of kinase activity can lead to uncontrolled cell growth. Casein kinase Iδ is known to interact with several key proteins, including β-catenin and p53, further highlighting casein kinase Iδ′s role in critical cellular processes. With broad species reactivity and versatility in various applications, anti-casein kinase Iδ antibody (E-10) is an invaluable tool for researchers studying the intricate mechanisms of cell signaling and regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
casein kinase Iδ Antibody (E-10) References:
- Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. | Akashi, M., et al. 2002. Mol Cell Biol. 22: 1693-703. PMID: 11865049
- Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. | Xu, Y., et al. 2005. Nature. 434: 640-4. PMID: 15800623
- Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. | Stöter, M., et al. 2005. Oncogene. 24: 7964-75. PMID: 16027726
- Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity. | Grozav, AG., et al. 2009. Nucleic Acids Res. 37: 382-92. PMID: 19043076
- Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms. | Sprouse, J., et al. 2010. Psychopharmacology (Berl). 210: 569-76. PMID: 20407760
- Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ. | Verkaar, F., et al. 2011. Chem Biol. 18: 485-94. PMID: 21513885
- Casein kinase iδ mutations in familial migraine and advanced sleep phase. | Brennan, KC., et al. 2013. Sci Transl Med. 5: 183ra56, 1-11. PMID: 23636092
- Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation. | Huang, Y., et al. 2014. PLoS Genet. 10: e1004536. PMID: 25211129
- Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization. | Kusuda, J., et al. 1996. Genomics. 32: 140-3. PMID: 8786104
- Crystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition. | Longenecker, KL., et al. 1998. Acta Crystallogr D Biol Crystallogr. 54: 473-5. PMID: 9761932
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
casein kinase Iδ Antibody (E-10) | sc-55554 | 200 µg/ml | $322.00 | |||
casein kinase Iδ Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-537074 | 200 µg Ab; 10 µg BP | $361.00 | |||
casein kinase Iδ Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-534260 | 200 µg Ab; 40 µg BP | $361.00 |