casein kinase Iδ Antibody (C-8): sc-55553

casein kinase Iδ Antibody (C-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects casein kinase I delta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-casein kinase Iδ antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. casein kinase I delta protein plays a crucial role in cellular signaling pathways, particularly in regulating circadian rhythms and cellular responses to DNA damage. Phosphorylation of various substrates by casein kinase I delta, including proteins involved in cell cycle regulation and apoptosis, underscores its importance in maintaining cellular homeostasis and responding to stress. Dysregulation of casein kinase I delta has been implicated in various diseases, including cancer and neurodegenerative disorders, making casein kinase I delta a significant target for therapeutic intervention. Understanding casein kinase I delta function and interactions within cells can provide valuable insights into disease mechanisms and potential treatment strategies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

casein kinase Iδ Antibody (C-8) References:

1. Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology.  |  Maritzen, T., et al. 2003. Eur J Cell Biol. 82: 369-78. PMID: 12924632
2. Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.  |  Tsai, IC., et al. 2007. Int J Cancer. 120: 1005-12. PMID: 17131344
3. Casein kinase I and II--multipotential serine protein kinases: structure, function, and regulation.  |  Tuazon, PT. and Traugh, JA. 1991. Adv Second Messenger Phosphoprotein Res. 23: 123-64. PMID: 1997039
4. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.  |  Lozeman, FJ., et al. 1990. Biochemistry. 29: 8436-47. PMID: 2174700
5. Casein kinase I delta controls centrosome positioning during T cell activation.  |  Zyss, D., et al. 2011. J Cell Biol. 195: 781-97. PMID: 22123863
6. Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta.  |  Graves, PR. and Roach, PJ. 1995. J Biol Chem. 270: 21689-94. PMID: 7665585
7. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes.  |  Zhai, L., et al. 1995. J Biol Chem. 270: 12717-24. PMID: 7759525
8. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.  |  Fish, KJ., et al. 1995. J Biol Chem. 270: 14875-83. PMID: 7797465
9. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.  |  Allende, JE. and Allende, CC. 1995. FASEB J. 9: 313-23. PMID: 7896000
10. Casein kinase II in signal transduction and cell cycle regulation.  |  Litchfield, DW. and Lüscher, B. 1993. Mol Cell Biochem. 127-128: 187-99. PMID: 7935350
11. Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.  |  Graves, PR., et al. 1993. J Biol Chem. 268: 6394-401. PMID: 8454611
12. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.  |  Rivers, A., et al. 1998. J Biol Chem. 273: 15980-4. PMID: 9632646

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-casein kinase Iδ Antibody (C-8) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-casein kinase Iδ Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

casein kinase Iδ Antibody (C-8) Specifications

Alternate Product Name: CSNK1D

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 296-355

Epitope Target: casein kinase Iδ

Epitope Species: human

Product Reactivity/Detection: casein kinase Iδ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for casein kinase Iδ Antibody (C-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin