casein kinase Iδ Activators
Casein kinase Iδ (CKIδ) activators are a class of chemical compounds that have garnered significant attention in the field of molecular biology and cell signaling research. These molecules are specifically designed to modulate the activity of CKIδ, a serine/threonine protein kinase that plays a crucial role in the regulation of various cellular processes. CKIδ belongs to the family of casein kinases, and its activation or inhibition can have profound effects on the cellular signaling pathways it participates in. CKIδ activators are designed to enhance the kinase's enzymatic activity, thereby influencing downstream signaling events.
These activators typically work by binding to CKIδ and promoting its phosphorylation of target proteins. By doing so, they can exert control over the timing and extent of various cellular processes, including the cell cycle, circadian rhythms, and DNA repair. The modulation of CKIδ activity is of particular interest in the context of circadian rhythm regulation, as CKIδ plays a key role in the phosphorylation of clock proteins, which govern the body's internal clock. Additionally, CKIδ has been implicated in various diseases, including cancer, making CKIδ activators potential tools for understanding and potentially manipulating these disease-associated pathways. Overall, CKIδ activators represent a class of compounds with great potential for advancing our understanding of cellular signaling and its role in health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may increase CKIδ expression by inhibiting glycogen synthase kinase-3 (GSK-3), a kinase that negatively regulates Wnt signaling. Enhanced Wnt signaling can lead to increased transcription of genes, potentially including those encoding for CKIδ. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $36.00 $64.00 $87.00 $413.00 $668.00 $65.00 | 8 | |
This compound, found in indole-3-carbinol found in cruciferous vegetables, has been shown to modulate various signaling pathways. It might induce CKIδ expression by affecting nuclear receptors and transcription factors, ultimately leading to changes in gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in grapes, has been shown to activate sirtuins, a family of NAD+-dependent deacetylases. Sirtuin activation can lead to changes in chromatin structure and gene expression, possibly including the upregulation of CKIδ. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) and activation of protein kinase A (PKA). The activation of this signaling cascade might lead to changes in gene expression, including the potential upregulation of CKIδ. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 can be converted to its active form, calcitriol, which binds to the vitamin D receptor (VDR) and modulates gene expression. The activation of VDR signaling has the potential to influence the expression of numerous genes, including CKIδ. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has been shown to modulate various signaling pathways and affect gene expression. It may influence CKIδ expression through its antioxidant properties or by modulating signaling pathways involved in cell growth and differentiation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, has been studied extensively for its effects on cellular signaling. It might upregulate CKIδ expression by modulating transcription factors and signaling pathways involved in inflammation and cell survival. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Found in cruciferous vegetables, sulforaphane has been shown to activate the Nrf2 pathway, which plays a key role in cellular responses to oxidative stress. Activation of Nrf2 could potentially lead to the upregulation of various genes, including CKIδ. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It may influence CKIδ expression through its ability to modulate signaling pathways involved in inflammation and cell survival, as well as through its effects on transcription factors. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulating gene expression. This binding can influence the expression of numerous genes, potentially including CKIδ, and play a role in processes such as cell differentiation and development. | ||||||