CARM1 Antibody (G-2): sc-393381
- CARM1 Antibody (G-2) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 578-608 at the C-terminus of CARM1 of mouse origin
- recommended for detection of CARM1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-393381 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CARM1 Antibody (G-2) for WB applications. These reagents are now offered in bundles with CARM1 Antibody (G-2) (see ordering information below).
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SEE ALSO...
CARM1 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects CARM1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CARM1, also known as protein arginine N-methyltransferase 4 (PRMT4), is a 585 amino acid protein located in both the nucleus and cytoplasm, playing a crucial role in gene expression regulation. Dual localization allows CARM1 to influence various cellular processes, including mRNA stability and transcriptional regulation, by modifying target proteins through methylation. This post-translational modification is essential for proper transcription factor functioning, as CARM1 acts as a positive regulator and secondary coactivator, enhancing p160 coactivator activity. CARM1 methyltransferase activity is controlled by phosphorylation at a conserved serine residue, highlighting the importance of post-translational modifications in regulating function. CARM1 exists in two alternatively spliced isoforms, and CARM1 gene is located on human chromosome 19p13.2, emphasizing biological significance and potential implications in various cellular contexts.
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CARM1 Antibody (G-2) References:
- The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis. | Zhang, LX., et al. 2022. Mol Cancer. 21: 110. PMID: 35525959
- CARM1 arginine methyltransferase as a therapeutic target for cancer. | Santos, M., et al. 2023. J Biol Chem. 299: 105124. PMID: 37536629
- CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy. | Stouth, DW., et al. 2024. Autophagy. 20: 1247-1269. PMID: 38018843
- Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1. | Garbutt, TA., et al. 2024. Circulation. 149: 1501-1515. PMID: 38223978
- Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity. | Itonaga, H., et al. 2024. Nat Commun. 15: 3415. PMID: 38649367
- CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development. | Chen, X., et al. 2024. Nucleic Acids Res. 52: 6811-6829. PMID: 38676947
- A CARM1 Inhibitor Potently Suppresses Breast Cancer Both In Vitro and In Vivo. | Peng, BL., et al. 2024. J Med Chem. 67: 7921-7934. PMID: 38713486
- ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation. | Cho, Y. and Kim, YK. 2024. Redox Biol. 73: 103212. PMID: 38838552
- Protein Arginine Methyltransferase CARM1 in Human Breast Cancer. | Bacabac, M., et al. 2024. Endocrinology. 165: PMID: 38878278
- CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence. | Cho, Y. and Kim, YK. 2024. Redox Biol. 76: 103344. PMID: 39265499
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CARM1 Antibody (G-2) | sc-393381 | 200 µg/ml | $316.00 | |||
CARM1 Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-538201 | 200 µg Ab; 10 µg BP | $354.00 | |||
CARM1 Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-535769 | 200 µg Ab; 40 µg BP | $354.00 | |||
CARM1 Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-545574 | 200 µg Ab; 20 µg BP | $354.00 | |||
CARM1 (G-2) Neutralizing Peptide | sc-393381 P | 100 µg/0.5 ml | $68.00 | |||
CARM1 Antibody (G-2) X | sc-393381 X | 200 µg/0.1 ml | $316.00 |