CARD 9 Antibody (F-4): sc-365545

CARD 9 Antibody (F-4) is a mouse monoclonal IgG2a antibody that detects CARD 9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CARD 9 plays a crucial role in the immune response, particularly in the recognition of fungal pathogens through interaction with the Dectin-1 receptor, which is essential for myeloid cell activation and subsequent cytokine production. This interaction is vital for innate anti-fungal immunity, as CARD 9 helps initiate a robust immune response against fungal infections. CARD 9 is primarily located in the cytoplasm and can translocate to the nucleus upon activation, where CARD 9 participates in the regulation of NFκB signaling pathways. Notably, CARD 9 self-associates and contains coiled-coil motifs that may facilitate oligomerization, enhancing signaling capabilities. Furthermore, CARD 9 interacts with Bcl10, a critical regulator of NFκB activation, linking CARD 9 to various immune signaling pathways. Dysregulation of CARD 9 expression has been associated with the development of gastric B-cell lymphoma, highlighting CARD 9′s importance in both immune function and disease pathology. anti-CARD 9 antibody (F-4) is an essential tool for researchers studying immune responses and related diseases.

The preferred CARD 9 antibody is CARD 9 Antibody (A-8): sc-374569.