CANT1 Antibody (C-3): sc-515574
- CANT1 Antibody (C-3) is a mouse monoclonal IgG2b κ CANT1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 145-233 mapping within an internal region of CANT1 of human origin
- CANT1 Antibody (C-3) is recommended for detection of CANT1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CANT1 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CANT1 Antibody (C-3) for WB applications. These reagents are now offered in bundles with CANT1 Antibody (C-3) (see ordering information below).
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CANT1 Antibody (C-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects CANT1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CANT1 antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CANT1, or calcium-activated nucleotidase 1, is a 401 amino acid single-pass type II membrane protein predominantly located in the endoplasmic reticulum and Golgi apparatus, where CANT1 plays a crucial role in nucleotide metabolism by hydrolyzing nucleotides such as UDP in a calcium-dependent manner. This enzymatic activity is vital for regulating nucleotide levels within cells, which can influence various cellular processes, including signal transduction and energy metabolism. CANT1 is expressed at particularly high levels in tissues such as the testis, placenta, prostate, and small intestine, and CANT1 undergoes post-translational N-glycosylation and alternative splicing, resulting in the production of two distinct isoforms. Notably, mutations in the CANT1 gene are linked to Desbuquois dysplasia, a rare autosomal recessive chondrodysplasia characterized by significant prenatal and postnatal growth retardation, underscoring the importance of CANT1 in normal development and cellular function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CANT1 Antibody (C-3) References:
- Clinical and genetic heterogeneity in Desbuquois dysplasia. | Faivre, L., et al. 2004. Am J Med Genet A. 128A: 29-32. PMID: 15211652
- Site-directed mutagenesis of human soluble calcium-activated nucleotidase 1 (hSCAN-1): identification of residues essential for enzyme activity and the Ca(2+)-induced conformational change. | Yang, M. and Kirley, TL. 2004. Biochemistry. 43: 9185-94. PMID: 15248776
- Characterization and importance of the dimer interface of human calcium-activated nucleotidase. | Yang, M., et al. 2008. Biochemistry. 47: 771-8. PMID: 18067325
- Engineered human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo. | Yang, M. and Kirley, TL. 2008. Thromb Res. 122: 541-8. PMID: 18222531
- Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer. | Hermans, KG., et al. 2008. Cancer Res. 68: 3094-8. PMID: 18451133
- Identification of CANT1 mutations in Desbuquois dysplasia. | Huber, C., et al. 2009. Am J Hum Genet. 85: 706-10. PMID: 19853239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CANT1 Antibody (C-3) | sc-515574 | 200 µg/ml | $322.00 | |||
CANT1 Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-525110 | 200 µg Ab, 40 µg BP | $361.00 | |||
CANT1 Antibody (C-3): m-IgG2b BP-HRP Bundle | sc-549213 | 200 µg Ab; 10 µg BP | $361.00 | |||
CANT1 Antibody (C-3) AC | sc-515574 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CANT1 Antibody (C-3) HRP | sc-515574 HRP | 200 µg/ml | $322.00 | |||
CANT1 Antibody (C-3) FITC | sc-515574 FITC | 200 µg/ml | $336.00 | |||
CANT1 Antibody (C-3) PE | sc-515574 PE | 200 µg/ml | $349.00 | |||
CANT1 Antibody (C-3) Alexa Fluor® 488 | sc-515574 AF488 | 200 µg/ml | $364.00 | |||
CANT1 Antibody (C-3) Alexa Fluor® 546 | sc-515574 AF546 | 200 µg/ml | $364.00 | |||
CANT1 Antibody (C-3) Alexa Fluor® 594 | sc-515574 AF594 | 200 µg/ml | $364.00 | |||
CANT1 Antibody (C-3) Alexa Fluor® 647 | sc-515574 AF647 | 200 µg/ml | $364.00 | |||
CANT1 Antibody (C-3) Alexa Fluor® 680 | sc-515574 AF680 | 200 µg/ml | $364.00 | |||
CANT1 Antibody (C-3) Alexa Fluor® 790 | sc-515574 AF790 | 200 µg/ml | $364.00 |