CANT1 Antibody (B-12): sc-515315

CANT1 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects CANT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CANT1, also known as calcium-activated nucleotidase 1, apyrase homolog, DBQD, or SCAN1, is a 401 amino acid single-pass type II membrane protein predominantly located in the endoplasmic reticulum and Golgi apparatus. Anti-CANT1 antibody (B-12) recognizes a calcium-dependent nucleotidase with a strong preference for binding uridine diphosphate (UDP), which is essential for various cellular processes, including nucleotide metabolism and signaling pathways. CANT1 is highly expressed in tissues such as the testis, placenta, prostate, and small intestine, and undergoes significant post-translational modifications, including N-glycosylation and alternative splicing, resulting in the production of two distinct isoforms. Notably, mutations in the CANT1 gene are linked to Desbuquois dysplasia, a rare autosomal recessive chondrodysplasia characterized by severe growth retardation both prenatally and postnatally, highlighting the importance of CANT1 in normal development and cellular function. CANT1 (B-12) antibody serves as an invaluable tool for researchers studying CANT1′s role in various biological contexts and disease states.

The preferred CANT1 antibody is CANT1 Antibody (C-3): sc-515574.