CAML Antibody (B-12): sc-166557
- CAML Antibody (B-12) is a mouse monoclonal IgG1 κ CAML antibody provided at 200 µg/ml
- raised against a peptide mapping near the N-terminus of CAML of human origin
- CAML Antibody (B-12) is recommended for detection of CAML of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-CAML Antibody (B-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CAML Antibody (B-12) for WB applications. These reagents are now offered in bundles with CAML Antibody (B-12) (see ordering information below).
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SEE ALSO...
CAML Antibody (B-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects CAML of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CAML antibody (B-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CAML, or calcium-signal modulating cyclophilin ligand, plays a crucial role in regulating calcium signaling pathways, which are essential for various cellular processes, including T cell activation and cytokine production. By modulating calcium influx, CAML acts as an important activator of the NFAT (nuclear factor of activated T cells) transcription factors, which are pivotal in regulating immune responses. The interaction between CAML and TACI (transmembrane activator and CAML-interactor), a member of the TNF receptor superfamily, further underscores its significance in immune signaling, as TACI can induce NFAT activation in the presence of CAML . CAML serves as a vital component in understanding T cell biology and the mechanisms underlying immune responses, highlighting potential therapeutic interventions in immune-related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CAML Antibody (B-12) References:
- Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | Bram, RJ. and Crabtree, GR. 1994. Nature. 371: 355-8. PMID: 7522304
- NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. | Ho, SN., et al. 1995. J Biol Chem. 270: 19898-907. PMID: 7650004
- NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction. | Rao, A. 1995. J Leukoc Biol. 57: 536-42. PMID: 7722411
- NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. | Masuda, ES., et al. 1995. Mol Cell Biol. 15: 2697-706. PMID: 7739550
- Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. | Hoey, T., et al. 1995. Immunity. 2: 461-72. PMID: 7749981
- Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. | Ho, S., et al. 1994. Adv Exp Med Biol. 365: 167-73. PMID: 7887301
- Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. | Timmerman, LA., et al. 1996. Nature. 383: 837-40. PMID: 8893011
- NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. | von Bülow, GU. and Bram, RJ. 1997. Science. 278: 138-41. PMID: 9311921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAML Antibody (B-12) | sc-166557 | 200 µg/ml | $322.00 | |||
CAML Antibody (B-12): m-IgG Fc BP-HRP Bundle | sc-528993 | 200 µg Ab; 10 µg BP | $361.00 | |||
CAML Antibody (B-12): m-IgGκ BP-HRP Bundle | sc-521655 | 200 µg Ab, 40 µg BP | $361.00 | |||
CAML Antibody (B-12): m-IgG1 BP-HRP Bundle | sc-543254 | 200 µg Ab; 20 µg BP | $361.00 | |||
CAML Antibody (B-12) AC | sc-166557 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CAML Antibody (B-12) HRP | sc-166557 HRP | 200 µg/ml | $322.00 | |||
CAML Antibody (B-12) FITC | sc-166557 FITC | 200 µg/ml | $336.00 | |||
CAML Antibody (B-12) PE | sc-166557 PE | 200 µg/ml | $349.00 | |||
CAML Antibody (B-12) Alexa Fluor® 488 | sc-166557 AF488 | 200 µg/ml | $364.00 | |||
CAML Antibody (B-12) Alexa Fluor® 546 | sc-166557 AF546 | 200 µg/ml | $364.00 | |||
CAML Antibody (B-12) Alexa Fluor® 594 | sc-166557 AF594 | 200 µg/ml | $364.00 | |||
CAML Antibody (B-12) Alexa Fluor® 647 | sc-166557 AF647 | 200 µg/ml | $364.00 | |||
CAML Antibody (B-12) Alexa Fluor® 680 | sc-166557 AF680 | 200 µg/ml | $364.00 | |||
CAML Antibody (B-12) Alexa Fluor® 790 | sc-166557 AF790 | 200 µg/ml | $364.00 | |||
CAML (B-12) Neutralizing Peptide | sc-166557 P | 100 µg/0.5 ml | $69.00 |