CaMKV Antibody (2F3-1A2): sc-517082

CaMKV Antibody (2F3-1A2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CaMKV protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-CaMKV antibody (2F3-1A2) is available as a non-conjugated monoclonal isotype antibody. The Ca2+/calmodulin-dependent protein kinases (CaMKs) represent a structurally related subfamily of serine/threonine kinases, and CAMKV (CaM kinase-like vesicle-associated), also known as 1G5 or VACAMKL, is a 501 amino acid protein that is primarily localized to cytoplasmic vesicles and the cell membrane, which is crucial for its role in cellular signaling and vesicle trafficking. Although CAMKV is considered catalytically inactive, CAMKV presence in these cellular compartments suggests involvement in regulating vesicle function and contributing to nervous system development. The gene encoding CAMKV is located on human chromosome 3, a region that harbors over 1,100 genes, including several key tumor suppressor genes and those associated with various genetic disorders such as Marfan Syndrome and von Hippel-Lindau syndrome. The existence of multiple isoforms of CAMKV due to alternative splicing further highlights the complexity of CAMKV function and potential interactions within cellular pathways, making CAMKV an important target for research in both normal physiology and disease states.

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CaMKV Antibody (2F3-1A2) References:

1. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.  |  Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
2. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
3. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
4. Phosphoproteomic analysis of the developing mouse brain.  |  Ballif, BA., et al. 2004. Mol Cell Proteomics. 3: 1093-101. PMID: 15345747
5. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
6. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'.  |  Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
7. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.  |  Liang, Z., et al. 2016. Nat Commun. 7: 13282. PMID: 27796283
8. Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain.  |  Shah, K. and Rossie, S. 2018. Mol Neurobiol. 55: 3426-3438. PMID: 28502042
9. CAMKV Is a Candidate Immunotherapeutic Target in MYCN Amplified Neuroblastoma.  |  Sussman, RT., et al. 2020. Front Oncol. 10: 302. PMID: 32211329
10. Palmitoylation-regulated interactions of the pseudokinase calmodulin kinase-like vesicle-associated with membranes and Arc/Arg3.1.  |  Barylko, B., et al. 2022. Front Synaptic Neurosci. 14: 926570. PMID: 35965782
11. Paraneoplastic Calmodulin Kinase-Like Vesicle-Associated Protein (CAMKV) Autoimmune Encephalitis.  |  Gilligan, M., et al. 2024. Ann Neurol. 96: 21-33. PMID: 38634529
12. 1G5: a calmodulin-binding, vesicle-associated, protein kinase-like protein enriched in forebrain neurites.  |  Godbout, M., et al. 1994. J Neurosci. 14: 1-13. PMID: 8283228

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CaMKV Antibody (2F3-1A2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CaMKV Antibody (2F3-1A2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CaMKV Antibody (2F3-1A2) Specifications

Alternate Product Name: CaMKV

Product Clone Name: 2F3-1A2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-501

Epitope Target: CaMKV

Epitope Species: human

Product Reactivity/Detection: CaMKV

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CaMKV Antibody (2F3-1A2): N/A