CaMKKα Antibody (6): sc-136280
- CaMKKα Antibody (6) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 341-504 of CaMKKα of rat origin
- recommended for detection of CaMKKα of mouse, rat, human and canine origin by WB, IP and IF; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CaMKKα Antibody (6). This work is in progress.
CaMKKα Antibody (6) is a mouse monoclonal IgG2a antibody that detects CaMKKα in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CaMKKα, or calcium/calmodulin-dependent protein kinase kinase alpha, plays a crucial role in cellular signaling by acting as a key regulator of CaMKI and CaMKIV, which are essential for various physiological processes, including metabolism, gene expression, and cell cycle progression. CaMKKα is primarily located in the cytoplasm, where activation by calcium ions and calmodulin enables phosphorylation and activation of downstream kinases. CaMKKα′s cytoplasmic localization allows rapid responses to changes in intracellular calcium levels, facilitating timely cellular responses to stimuli. Additionally, CaMKKα interacts with several other proteins, including AMP-activated protein kinase (AMPK), which further underscores its significance in metabolic regulation and energy homeostasis. Anti-CaMKKα antibody (6) serves as an invaluable tool for researchers studying calcium signaling pathways and their implications in various biological processes and diseases.
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CaMKKα Antibody (6) References:
- Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation. | Witczak, CA., et al. 2007. Diabetes. 56: 1403-9. PMID: 17287469
- A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome. | Dong, F., et al. 2017. Stem Cells Transl Med. 6: 1759-1766. PMID: 28688176
- Discovery of potent Camkk1 kinase inhibitors through e-pharmacophore and molecular screening approaches. | Prajisha, J., et al. 2022. J Biomol Struct Dyn. 40: 2740-2756. PMID: 33155526
- Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases. | Beghi, S., et al. 2021. Biosci Rep. 41: PMID: 34165505
- Associations Between CAMKK1 Polymorphism rs7214723 and the Prognosis of Patients With Lung Cancer. | Zhang, H., et al. 2021. Front Oncol. 11: 757484. PMID: 34868969
- Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis. | Zhao, Y., et al. 2023. Bioact Mater. 26: 249-263. PMID: 36936807
- 14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices. | Petrvalska, O., et al. 2023. Protein Sci. 32: e4805. PMID: 37817008
- Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2). | Chen, Y., et al. 2023. J Med Chem. 66: 15750-15760. PMID: 38009718
- Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study. | Nakamura, Y., et al. 1996. Neurosci Lett. 204: 61-4. PMID: 8929978
- Studies on the substrate specificity of Ca2+/calmodulin-dependent protein kinase kinase alpha. | Okuno, S., et al. 1997. J Biochem. 122: 337-43. PMID: 9378711
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CaMKKα Antibody (6) | sc-136280 | 50 µg/0.5 ml | $316.00 |