CaMK Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NH125 | 278603-08-0 | sc-203037 | 5 mg | $191.00 | 1 | |
NH125 functions as a potent calcium/calmodulin-dependent protein kinase (CaMK) modulator, exhibiting unique binding affinities that enhance its interaction with specific substrates. Its distinct molecular structure facilitates rapid phosphorylation events, influencing downstream signaling cascades. The compound's kinetic profile reveals a remarkable ability to stabilize transient protein conformations, thereby optimizing enzymatic activity and promoting efficient signal amplification within cellular networks. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol acts as a selective modulator of calcium/calmodulin-dependent protein kinases (CaMKs), characterized by its unique ability to form stable complexes with target proteins. This compound exhibits distinct allosteric effects, altering the conformational dynamics of CaMKs and enhancing substrate accessibility. Its interaction kinetics reveal a preference for specific phosphorylation sites, leading to nuanced regulation of cellular signaling pathways and influencing various biological processes. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 is a potent inhibitor of calcium/calmodulin-dependent protein kinases (CaMKs), distinguished by its capacity to disrupt calcium-mediated signaling. This compound engages in specific molecular interactions that stabilize the inactive conformation of CaMKs, effectively blocking substrate binding. Its unique binding affinity alters the kinetics of phosphorylation reactions, providing a nuanced modulation of downstream signaling pathways and cellular responses. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a selective inhibitor of calcium/calmodulin-dependent protein kinases (CaMKs), characterized by its ability to interfere with calcium-dependent activation. This compound exhibits unique binding dynamics, favoring a conformational shift that prevents the transition to the active state of CaMKs. By modulating the enzyme's interaction with calmodulin, ML-9 alters the kinetics of phosphorylation, impacting various cellular signaling cascades and regulatory mechanisms. | ||||||
H-7, Dihydrochloride | 108930-17-2 | sc-24009 sc-24009A | 10 mg 50 mg | $80.00 $319.00 | ||
H-7, Dihydrochloride acts as a potent inhibitor of calcium/calmodulin-dependent protein kinases (CaMKs) by disrupting the enzyme's interaction with its regulatory partner, calmodulin. This compound uniquely stabilizes an inactive conformation, thereby hindering the phosphorylation process. Its distinct molecular interactions lead to altered reaction kinetics, influencing downstream signaling pathways and cellular responses. The compound's specificity for CaMKs highlights its role in modulating critical regulatory networks. | ||||||
W-13 Isomer hydrochloride | 88519-57-7 | sc-222413 sc-222413A sc-222413B | 1 mg 5 mg 10 mg | $38.00 $121.00 $188.00 | 1 | |
W-13 Isomer hydrochloride acts as a potent modulator of calcium/calmodulin-dependent protein kinases (CaMKs) through its ability to form specific electrostatic interactions with key residues in the enzyme's active site. This interaction promotes a unique conformational shift, enhancing the enzyme's affinity for calcium ions and accelerating reaction kinetics. The compound's distinct structural features facilitate selective pathway activation, influencing downstream signaling networks and cellular responses. | ||||||
Indole-3-acetamide | 879-37-8 | sc-255213 sc-255213A | 1 g 5 g | $44.00 $198.00 | 1 | |
Indole-3-acetamide functions as a selective modulator of calcium/calmodulin-dependent protein kinases (CaMKs) by engaging in unique hydrogen bonding interactions that stabilize the enzyme's inactive state. This stabilization alters the conformational dynamics of the kinase, effectively slowing reaction kinetics and impacting substrate phosphorylation. Its distinct molecular behavior influences various signaling cascades, underscoring its role in fine-tuning cellular regulatory mechanisms. | ||||||