CaMKII beta Antibody (D-6): sc-376828

CaMKIIβ Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the C-terminal epitope of the Ca²⁺/calmodulin-dependent protein kinase II beta (CaMKIIβ) between amino acids 511-540 of mouse origin. CaMKIIβ monoclonal antibody (D-6) exhibits broad species reactivity, effectively recognizing CaMKIIβ from mouse, rat, human, canine, and bovine origins across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated form and multiple conjugated forms such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, anti-CaMKIIβ antibody (D-6) offers versatile options for diverse experimental needs. CaMKIIβ, also called CAM2, CAMK2, CAMKB, CaMKIIbeta, and MRD54, is a critical member of the Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) family, which plays a pivotal role in translating calcium signals into cellular responses. Located predominantly in the cytoplasm and dendrites of neurons, CaMKIIβ is essential for synaptic plasticity, learning, and memory by regulating the strength and formation of synaptic connections. CaMKIIβ′s strategic localization within the cell allows for effective modulation of phosphorylation of various substrates involved in neurotransmitter release, cytoskeletal rearrangements, and gene expression, thereby influencing neuronal communication and plasticity. Beyond the nervous system, CaMKIIβ is involved in the regulation of the cell cycle, transcription, and other critical cellular processes, making CaMKIIβ indispensable for maintaining cellular homeostasis and responding to environmental stimuli. The precise detection and study of CaMKIIβ using anti-CaMKIIβ antibody (D-6) enable researchers to investigate spatial and temporal dynamics, elucidate role in signal transduction pathways, and understand contributions to both normal physiological functions and pathological conditions such as neurodegenerative diseases, cancer, and cardiovascular disorders.

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CaMKII beta Antibody (D-6) References:

1. The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme.  |  Baltas, LG., et al. 1995. FEBS Lett. 373: 71-5. PMID: 7589437
2. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.  |  Tokumitsu, H., et al. 1995. J Biol Chem. 270: 19320-4. PMID: 7642608
3. Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.  |  Hama, N., et al. 1995. J Exp Med. 181: 1217-22. PMID: 7869038
4. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).  |  Tombes, RM., et al. 1995. Cell Growth Differ. 6: 1063-70. PMID: 8519682
5. Overexpression of Ca2+/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 cells.  |  Tashima, K., et al. 1996. J Neurochem. 66: 57-64. PMID: 8522989
6. Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes.  |  Park, IK. and Soderling, TR. 1995. J Biol Chem. 270: 30464-9. PMID: 8530476

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CaMKII beta Antibody (D-6) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-CaMKII beta Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CaMKII beta Antibody (D-6) Specifications

Alternate Product Name: CAMK2B

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 511-540

Epitope Target: CaMKIIβ

Epitope Species: mouse

Product Reactivity/Detection: CaMKIIβ and CaMKIIδ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for CaMKII beta Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred p-CaMKII antibody is p-CaMKII Antibody (22B1): sc-32289.