CaMKI Antibody (H-8): sc-137225

CaMKI Antibody (H-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects CaMKI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CaMKI antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CaMKI, a member of the calcium/calmodulin-dependent protein kinase family, plays a crucial role in cellular signaling pathways by phosphorylating serine and threonine residues on target proteins, which is essential for regulating various physiological processes such as cell growth, differentiation, and apoptosis. CaMKI is primarily located in the cytoplasm and can translocate to the nucleus upon activation, highlighting its importance in mediating calcium signaling and influencing gene expression. Additionally, CaMKI is activated through the binding of calcium-bound calmodulin, which underscores the significance of calcium as a second messenger in cellular responses. Understanding the function and regulation of CaMKI is vital for elucidating its role in health and disease, particularly in conditions where calcium signaling is disrupted.

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CaMKI Antibody (H-8) References:

1. CaMKK-CaMKI signaling pathways differentially control axon and dendrite elongation in cortical neurons.  |  Neal, AP., et al. 2010. J Neurosci. 30: 2807-9. PMID: 20181577
2. A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion.  |  Chang, CW., et al. 2011. Mol Cell Biol. 31: 3820-31. PMID: 21791615
3. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion.  |  Chang, CW., et al. 2013. Mol Hum Reprod. 19: 745-55. PMID: 23867755
4. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.  |  Neal, SJ., et al. 2015. Elife. 4: PMID: 26335407
5. 1800 MHz radiofrequency fields inhibits testosterone production via CaMKI /RORα pathway.  |  Qin, F., et al. 2018. Reprod Toxicol. 81: 229-236. PMID: 30125682
6. Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation.  |  Ippolito, D., et al. 2021. Elife. 10: PMID: 34766550
7. The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme.  |  Baltas, LG., et al. 1995. FEBS Lett. 373: 71-5. PMID: 7589437
8. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.  |  Tokumitsu, H., et al. 1995. J Biol Chem. 270: 19320-4. PMID: 7642608
9. Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.  |  Hama, N., et al. 1995. J Exp Med. 181: 1217-22. PMID: 7869038
10. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).  |  Tombes, RM., et al. 1995. Cell Growth Differ. 6: 1063-70. PMID: 8519682
11. Overexpression of Ca2+/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 cells.  |  Tashima, K., et al. 1996. J Neurochem. 66: 57-64. PMID: 8522989
12. Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes.  |  Park, IK. and Soderling, TR. 1995. J Biol Chem. 270: 30464-9. PMID: 8530476

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CaMKI Antibody (H-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CaMKI Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CaMKI Antibody (H-8) Specifications

Alternate Product Name: CAMK1

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 246-370

Epitope Target: CaMKI

Epitope Species: human

Product Reactivity/Detection: CaMKI and CaMKIδ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CaMKI Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin